2-(4,4-Difluorocyclohex-1-en-1-yl)-4,4,5,5-tetraMethyl-1,3,2-dioxaborolane

Base Information

Chemical Name:2-(4,4-Difluorocyclohex-1-en-1-yl)-4,4,5,5-tetraMethyl-1,3,2-dioxaborolane
CAS No.:1227068-84-9
Molecular Formula:C12H19BF2O2
Molecular Weight:244.089
Hs Code.:
Mol file:1227068-84-9.mol

Synonyms:2-(4,4-Difluorocyclohex-1-en-1-yl)-4,4,5,5-tetraMethyl-1,3,2-dioxaborolane;4,4-Difluorocyclohex-1-enylboronic acid pinacol ester;4,4-difluorocyclohexyl boronic ester;2-(4,4-difluorocyclohex-1-enyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane;4,4-Difluorocyclohexene-1-boronic Acid Pinacol Ester;2-(4,4-difluorocyclohexen-1-yl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane

Suppliers and Price of 2-(4,4-Difluorocyclohex-1-en-1-yl)-4,4,5,5-tetraMethyl-1,3,2-dioxaborolane

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
2-(4,4-Difluoro-1-cyclohexen-1-yl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane
500mg
$ 165.00

Synthonix
2-(4,4-difluorocyclohex-1-en-1-yl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane 97.0%
1g
$ 130.00

SynChem
2-(4,4-DIFLUOROCYCLOHEX-1-EN-1-YL)-4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLANE 95%
1 g
$ 428.00

Crysdot
2-(4,4-Difluorocyclohex-1-en-1-yl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane 95+%
1g
$ 135.00

Crysdot
2-(4,4-Difluorocyclohex-1-en-1-yl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane 95+%
5g
$ 440.00

Chemenu
2-(4,4-difluorocyclohex-1-en-1-yl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane 95%
10g
$ 920.00

Chemcia Scientific
4,4-Difluorocyclohex-1-enylboronicacidpinacolester ＞97%
5 G
$ 440.00

Ambeed
2-(4,4-Difluorocyclohex-1-en-1-yl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane 97%
5g
$ 366.00

Ambeed
2-(4,4-Difluorocyclohex-1-en-1-yl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane 97%
250mg
$ 37.00

Ambeed
2-(4,4-Difluorocyclohex-1-en-1-yl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane 97%
100mg
$ 21.00

Total 26 raw suppliers

Chemical Property of 2-(4,4-Difluorocyclohex-1-en-1-yl)-4,4,5,5-tetraMethyl-1,3,2-dioxaborolane

Chemical Property:

Boiling Point:233.3±50.0 °C(Predicted)
PSA：18.46000
Density:1.06±0.1 g/cm3(Predicted)
LogP:3.36340
Storage Temp.:Inert atmosphere,Store in freezer, under -20°C

Purity/Quality:

97% ^*data from raw suppliers

2-(4,4-Difluoro-1-cyclohexen-1-yl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Uses 2-(4,4-Difluoro-1-cyclohexen-1-yl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane, is used as a reagent in the preparation of 4-(cycloalkanyloxy)benzenesulfonamide derivatives as inhibitors of voltage-gated sodium channel for prevention and treatment of pains.

Technology Process of 2-(4,4-Difluorocyclohex-1-en-1-yl)-4,4,5,5-tetraMethyl-1,3,2-dioxaborolane

There total 3 articles about 2-(4,4-Difluorocyclohex-1-en-1-yl)-4,4,5,5-tetraMethyl-1,3,2-dioxaborolane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 49.5%

: 22515-18-0
4,4-difluorocyclohexanone

: 73183-34-3
bis(pinacol)diborane

: 1227068-84-9
2-(4,4-difluorocyclohex-1-en-1-yl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane

Guidance literature:: 4,4-difluorocyclohexanone; In tetrahydrofuran; at -78 ℃; for 1h; Alkaline conditions;

With N,N-phenylbistrifluoromethane-sulfonimide; In tetrahydrofuran; at -78 - 20 ℃; for 16h;

bis(pinacol)diborane; With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium acetate; In 1,4-dioxane; at 100 ℃; for 16h;

Reference yield:

: 1227068-83-8
trifluoromethane sulfonic acid 4,4-difluorocyclohex-1-en-1-yl ester

: 73183-34-3
bis(pinacol)diborane

: 1227068-84-9
2-(4,4-difluorocyclohex-1-en-1-yl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane

Guidance literature:: With potassium acetate; 1,1'-bis(diphenylphosphino)ferrocene; In 1,4-dioxane; at 130 ℃;

Reference yield:

: 22515-18-0
4,4-difluorocyclohexanone

: 1227068-84-9
2-(4,4-difluorocyclohex-1-en-1-yl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane

Guidance literature:: Multi-step reaction with 2 steps

1: lithium hexamethyldisilazane / tetrahydrofuran / 16 h / -78 - 25 °C

2: potassium acetate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / 1,4-dioxane / 16 h / 130 °C

With dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; potassium acetate; lithium hexamethyldisilazane; In tetrahydrofuran; 1,4-dioxane;