4,6-Dihydrothieno[3,4-b]thiophene-2-carboxylic acid

Base Information

• Chemical Name: 4,6-Dihydrothieno[3,4-b]thiophene-2-carboxylic acid
• CAS No.: 7712-05-2
• Molecular Formula: C7H6O2S2
• Molecular Weight: 186.25
• Hs Code.: 2934999090
• Mol file: 7712-05-2.mol

Synonyms:4,6-Dihydrothieno[3,4-b]thiophene-2-carboxylic acid

Chemical Property of 4,6-Dihydrothieno[3,4-b]thiophene-2-carboxylic acid

Chemical Property:

• Melting Point: 240°C(lit.)
• PSA: 90.84000
• Density: 1.551
• LogP: 2.19310
• Storage Temp.: 2-8°C(protect from light)

Purity/Quality:

98%,99%, ^*data from raw suppliers

4,6-Dihydrothieno[3,4-b]thiophene-2-carboxylic Acid ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 4,6-Dihydrothieno[3,4-b]thiophene-2-carboxylic acid can be used as organic synthesis intermediates and pharmaceutical intermediates, mainly used in laboratory research and development processes and pharmaceutical and chemical production processes.

Technology Process of 4,6-Dihydrothieno[3,4-b]thiophene-2-carboxylic acid

There total 4 articles about 4,6-Dihydrothieno[3,4-b]thiophene-2-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

4,6-Dihydro-thieno[3,4-b]thiophene-2-carboxylic acid methyl ester (7767-60-4) → 4,6-dihydrothieno[3,4-b]thiophene-2-carboxylic acid (7712-05-2)

Guidance literature:

With ethanol; potassium hydroxide; at 78 ℃; for 4h;

Reference yield:

thiophene-2-carboxylic acid methyl ester (5380-42-7) → 4,6-dihydrothieno[3,4-b]thiophene-2-carboxylic acid (7712-05-2)

Guidance literature:

Multi-step reaction with 3 steps

1: zinc(II) chloride / 6 h / 50 °C

2: sodium sulfide / methanol / 5 h / 70 °C

3: potassium hydroxide; ethanol / 4 h / 78 °C

With sodium sulfide; ethanol; potassium hydroxide; zinc(II) chloride; In methanol;

Reference yield:

4,5-Bis-chloromethyl-thiophene-2-carboxylic acid methyl ester (7353-89-1) → 4,6-dihydrothieno[3,4-b]thiophene-2-carboxylic acid (7712-05-2)

Guidance literature:

Multi-step reaction with 2 steps

1: sodium sulfide / methanol / 5 h / 70 °C

2: potassium hydroxide; ethanol / 4 h / 78 °C

With sodium sulfide; ethanol; potassium hydroxide; In methanol;

upstream raw materials:

thiophene-2-carboxylic acid methyl ester

4,5-Bis-chloromethyl-thiophene-2-carboxylic acid methyl ester

4,6-Dihydro-thieno[3,4-b]thiophene-2-carboxylic acid methyl ester

Downstream raw materials:

thieno[3,4-b]thiophene-2-carboxylic acid

Refernces

• 1、 -. "Fused-heterocycle compound and preparation method thereof". . . Retrieved 2017/06/23.