3-Bromo-2-chloro-5-iodopyridine

Base Information

• Chemical Name: 3-Bromo-2-chloro-5-iodopyridine
• CAS No.: 1211586-80-9
• Molecular Formula: C5H2BrClIN
• Molecular Weight: 318.34
• Hs Code.: 2933399090
• European Community (EC) Number: 866-242-1
• DSSTox Substance ID: DTXSID90697685
• Wikidata: Q82627659
• Mol file: 1211586-80-9.mol

Synonyms:3-BROMO-2-CHLORO-5-IODOPYRIDINE;1211586-80-9;SCHEMBL10305653;DTXSID90697685;MFCD13185354;AKOS016006958;CS-W021853;DS-2559;FT-0730155;I11218;A891869

Chemical Property of 3-Bromo-2-chloro-5-iodopyridine

Chemical Property:

• PSA: 12.89000
• LogP: 3.10210
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C
• XLogP3: 3.2
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 1
• Rotatable Bond Count: 0
• Exact Mass: 316.81039
• Heavy Atom Count: 9
• Complexity: 103

Purity/Quality:

97% ^*data from raw suppliers

3-Bromo-2-chloro-5-iodopyridine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=C(C=NC(=C1Br)Cl)I

Technology Process of 3-Bromo-2-chloro-5-iodopyridine

There total 2 articles about 3-Bromo-2-chloro-5-iodopyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

5-amino-3-bromo-2-chloropyridine (130284-53-6) → 3-bromo-2-chloro-5-iodopyridine (1211586-80-9)

Guidance literature:

5-amino-3-bromo-2-chloropyridine; With hydrogenchloride; sodium nitrite; In water; at 0 ℃; for 1h;

In water; at 0 - 20 ℃;

DOI:10.1021/acs.jmedchem.7b00076

Reference yield: 63.0%

2-amino-3-bromo-5-iodopyridine (697300-73-5) → 3-bromo-2-chloro-5-iodopyridine (1211586-80-9)

Guidance literature:

With hydrogenchloride; sodium nitrite; In water; at -20 - 20 ℃; for 4h;

DOI:10.1021/acs.joc.6b00413

Reference yield: 46.0%

3-bromo-2-chloro-5-iodopyridine (1211586-80-9) + (R)-2-amino-2-(4-fluorophenyl)ethanol (174770-74-2) → (R)-2-((5-bromo-6-chloropyridin-3-yl)amino)-2-(4-fluorophenyl)-ethan-1-ol

Guidance literature:

With potassium phosphate; copper(l) iodide; In 1,2-dimethoxyethane; isopropyl alcohol; at 80 ℃; for 14h; Inert atmosphere;

DOI:10.1021/acs.jmedchem.1c01148

upstream raw materials:

2-amino-3-bromo-5-iodopyridine

5-amino-3-bromo-2-chloropyridine

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