3-Methoxyestra-1,3,5(10),8-tetraen-17beta-ol

Base Information

• Chemical Name: 3-Methoxyestra-1,3,5(10),8-tetraen-17beta-ol
• CAS No.: 2919-30-4
• Molecular Formula: C₁₉H₂₄O₂
• Molecular Weight: 284.398
• Mol file: 2919-30-4.mol

Synonyms:3-METHOXY-ESTRA-1,3,5(10),8(9)-TETRAEN-17SS-OL;(17B)-(+/-)-3-METHOXYESTRA-1,3,5(10),8-TETRAEN-17-OL;3-METHOXYESTRA-1,3,5(10),8-TETRAEN-17B-OL;3-METHOXY-ESTRA-1,3,5(10),8(9)-TETRAEN-17BETA-OL;

Chemical Property of 3-Methoxyestra-1,3,5(10),8-tetraen-17beta-ol

Chemical Property:

• Melting Point: 131-132℃
• PSA: 29.46000
• Density: 1.16
• LogP: 3.96600

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3-Methoxyestra-1,3,5(10),8-tetraen-17beta-ol

There total 13 articles about 3-Methoxyestra-1,3,5(10),8-tetraen-17beta-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

3-methoxyestra-1,3,5(10),8,14-pentaen-17-one (1456-50-4) → (+/-)-3-Methoxy-18-methylestra-1,3,5(10),8-tetraen-17β-ol (2919-30-4,4820-53-5,6733-79-5,15426-92-3,17021-76-0,19119-76-7,24508-24-5,98819-88-6)

Guidance literature:

Multi-step reaction with 2 steps

1: H₂ / Pd-CaCO₃

2: NaBH₄

With sodium tetrahydroborate; hydrogen; Lindlar's catalyst;

DOI:10.1039/jr9630005072

Reference yield:

2-Methylcyclopentane-1,3-dione (765-69-5) → (+/-)-3-Methoxy-18-methylestra-1,3,5(10),8-tetraen-17β-ol (2919-30-4,4820-53-5,6733-79-5,15426-92-3,17021-76-0,19119-76-7,24508-24-5,98819-88-6)

Guidance literature:

Multi-step reaction with 4 steps

1: KOH

2: aq. HCl

3: H₂ / Pd-CaCO₃

4: NaBH₄

With hydrogenchloride; potassium hydroxide; sodium tetrahydroborate; hydrogen; Lindlar's catalyst;

DOI:10.1039/jr9630005072

Reference yield:

2-[2-(3,4-dihydro-6-methoxy-1(2H)-naphthalenylidene)ethyl]-2-methyl-1,3-cyclopentanedione (899-79-6) → (+/-)-3-Methoxy-18-methylestra-1,3,5(10),8-tetraen-17β-ol (2919-30-4,4820-53-5,6733-79-5,15426-92-3,17021-76-0,19119-76-7,24508-24-5,98819-88-6)

Guidance literature:

Multi-step reaction with 3 steps

1: aq. HCl

2: H₂ / Pd-CaCO₃

3: NaBH₄

With hydrogenchloride; sodium tetrahydroborate; hydrogen; Lindlar's catalyst;

DOI:10.1039/jr9630005072

upstream raw materials:

(+/-)-3-methoxyestra-1,3,5⁽¹⁰⁾,8-tetraen-17-one

3-methoxyestra-1,3,5(10),8,14-pentaen-17β-ol

(+/-)-3-Methoxyestra-1,3,5(10),8(14),9,15-hexaen-17β-ol

2-Methylcyclopentane-1,3-dione

Downstream raw materials:

(+/-)-3-methoxyestra-1,3,5⁽¹⁰⁾,6,8-pentaen-17-one

rac-14β-Oestra-1,3,5(10),6,8-pentaen-3,17β-diol

rac-3,17-β-Dihydroxy-oestra-1,3,5(10),8-tetraen

rac-3-hydroxy-estratetraen-(A_.8)-one-⁽¹⁷⁾