PIVALOYLOXYMETHYL 6-AMINOPENICILANATE

Base Information

• Chemical Name: PIVALOYLOXYMETHYL 6-AMINOPENICILANATE
• CAS No.: 25031-08-7
• Molecular Formula: C14H22N2O5S
• Molecular Weight: 330.4
• Mol file: 25031-08-7.mol

Synonyms:6-Amino-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid hydroxymethyl pivalate ester;

Chemical Property of PIVALOYLOXYMETHYL 6-AMINOPENICILANATE

Chemical Property:

• PSA: 124.23000
• LogP: 1.10420

Purity/Quality:

98%min ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of PIVALOYLOXYMETHYL 6-AMINOPENICILANATE

There total 2 articles about PIVALOYLOXYMETHYL 6-AMINOPENICILANATE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

6-Aminopenicillanic Acid (551-16-6) + Chloromethyl pivalate (18997-19-8) → 6-aminopenicillanic acid pivaloyloxymethyl ester (25031-08-7)

Guidance literature:

With 1,8-diazabicyclo[5.4.0]undec-7-ene; In dichloromethane; acetonitrile; at 20 ℃; for 1h;

DOI:10.1039/P19880002059

Reference yield:

→ 6-Amino-3,3-dimethyl-7-oxo-4-thia-1-aza-bicyclo[3.2.0]heptane-2-carboxylic acid 2,2-dimethyl-propionyloxymethyl ester (25031-08-7,81658-75-5)

Guidance literature:

6-Aminopenicillansaeure , Chlormethylpivalat;

Reference yield: 100.0%

benzylamine (100-46-9) + 6-aminopenicillanic acid pivaloyloxymethyl ester (25031-08-7) → (2R,4S)-2-((R)-Amino-benzylcarbamoyl-methyl)-5,5-dimethyl-thiazolidine-4-carboxylic acid 2,2-dimethyl-propionyloxymethyl ester

Guidance literature:

In dichloromethane; at 20 ℃;

upstream raw materials:

6-Aminopenicillanic Acid

Chloromethyl pivalate

Downstream raw materials:

6β-[(N-cyano-benzimidoyl)-amino]-penicillanic acid 2,2-dimethyl-propionyloxymethyl ester

6β-[(N-cyano-2-phenyl-acetimidoyl)-amino]-penicillanic acid 2,2-dimethyl-propionyloxymethyl ester

6β-{[2-(4-chloro-phenyl)-N-cyano-acetimidoyl]-amino}-penicillanic acid 2,2-dimethyl-propionyloxymethyl ester

3-Methyl-2-[(3R,4R)-2-oxo-3-(2-oxo-propyl)-4-phenylacetylsulfanyl-azetidin-1-yl]-but-2-enoic acid 2,2-dimethyl-propionyloxymethyl ester