1,3-Difluoro-5-Methyl-2-Nitrobenzene

Base Information

• Chemical Name: 1,3-Difluoro-5-Methyl-2-Nitrobenzene
• CAS No.: 932373-92-7
• Molecular Formula: C7H5F2NO2
• Molecular Weight: 173.119
• Hs Code.: 2904990090
• Mol file: 932373-92-7.mol

Synonyms:3.5-DIFLUORO-4-NITROTOLUENE;

Chemical Property of 1,3-Difluoro-5-Methyl-2-Nitrobenzene

Chemical Property:

• Boiling Point: 256.3±35.0℃ (760 Torr)
• Flash Point: 125.5±14.2℃
• PSA: 45.82000
• Density: 1.374±0.06 g/cm3 (20 oC 760 Torr)
• LogP: 2.70460
• Storage Temp.: Sealed in dry,Room Temperature

Purity/Quality:

98%min ^*data from raw suppliers

1,3-Difluoro-5-methyl-2-nitrobenzene ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1,3-Difluoro-5-Methyl-2-Nitrobenzene

There total 3 articles about 1,3-Difluoro-5-Methyl-2-Nitrobenzene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(3,5-difluoro-4-nitrophenyl)acetic acid (932373-91-6) → 1,3-difluoro-5-methyl-2-nitrobenzene (932373-92-7)

Guidance literature:

(3,5-difluoro-4-nitrophenyl)acetic acid; With potassium carbonate; In N,N-dimethyl-formamide; at 50 ℃; for 0.5h;

In hexane; water; N,N-dimethyl-formamide; at 25 ℃; for 0.166667h;

Reference yield:

tert-butyl (3,5-difluoro-4-nitrophenyl)acetate (288580-60-9) → 1,3-difluoro-5-methyl-2-nitrobenzene (932373-92-7)

Guidance literature:

Multi-step reaction with 2 steps

1: hydrogenchloride / 1,4-dioxane / 18 h / 25 °C

2: potassium carbonate / N,N-dimethyl-formamide / 0.5 h / 50 °C

With hydrogenchloride; potassium carbonate; In 1,4-dioxane; N,N-dimethyl-formamide;

Reference yield:

2,6-difluoro-1-nitrobenzene (19064-24-5) → 1,3-difluoro-5-methyl-2-nitrobenzene (932373-92-7)

Guidance literature:

Multi-step reaction with 3 steps

1: potassium tert-butylate / 1-methyl-pyrrolidin-2-one / 2 h / -20 - -10 °C

2: hydrogenchloride / 1,4-dioxane / 18 h / 25 °C

3: potassium carbonate / N,N-dimethyl-formamide / 0.5 h / 50 °C

With hydrogenchloride; potassium tert-butylate; potassium carbonate; In 1,4-dioxane; 1-methyl-pyrrolidin-2-one; N,N-dimethyl-formamide;

upstream raw materials:

(3,5-difluoro-4-nitrophenyl)acetic acid

tert-butyl (3,5-difluoro-4-nitrophenyl)acetate

2,6-difluoro-1-nitrobenzene

Downstream raw materials:

2,6-difluoro-4-methylaniline

N-(3-fluoro-5-methyl-2-nitrophenyl)-1-(tetrahydro-2H-pyran-4-yl)-4-piperidinamine

Refernces

• 1、 -. "COMPOUNDS WHICH HAVE ACTIVITY AT M1 RECEPTOR AND THEIR USES IN MEDICINE". Page/Page column 60-61. . Retrieved 2010/11/26.