2,6-Difluoro-4-Methyl aniline

Base Information

• Chemical Name: 2,6-Difluoro-4-Methyl aniline
• CAS No.: 1379028-84-8
• Molecular Formula: C7H7F2N
• Molecular Weight: 143.1339864
• Mol file: 1379028-84-8.mol

Synonyms:2,6-difluoro-4-methylaniline;

Chemical Property of 2,6-Difluoro-4-Methyl aniline

Chemical Property:

• Boiling Point: 172.7±35.0 °C(Predicted)
• PKA: 2.24±0.10(Predicted)
• PSA: 26.02000
• Density: 1.229±0.06 g/cm3(Predicted)
• LogP: 2.43660
• Storage Temp.: 2-8°C(protect from light)

Purity/Quality:

97% purity ^*data from raw suppliers

2,6-Difluoro-4-methylaniline 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2,6-Difluoro-4-Methyl aniline

There total 1 articles about 2,6-Difluoro-4-Methyl aniline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

1,3-difluoro-5-methyl-2-nitrobenzene (932373-92-7) → 2,6-difluoro-4-methylaniline (1379028-84-8)

Guidance literature:

With palladium 10% on activated carbon; hydrogen; In ethanol; for 3h; under 760.051 Torr;

DOI:10.1021/acs.jmedchem.8b01822

Reference yield: 100.0%

2,6-difluoro-4-methylaniline (1379028-84-8) + 4-Chlorobutanoyl chloride (4635-59-0) → 4-chloro-N-(2,6-difluoro-4-methylphenyl)butanamide

Guidance literature:

With triethylamine; In dichloromethane; at 0 - 25 ℃; for 6h;

DOI:10.1021/acs.joc.8b01562

Reference yield: 43.0%

2,6-difluoro-4-methylaniline (1379028-84-8) + 1,3-difluoro-2-nitrosobenzene (29270-54-0) → 1-(2,6-difluoro-4-methylphenyl)-2-(2,6-difluorophenyl)-diazene

Guidance literature:

With acetic acid; trifluoroacetic acid; In toluene; at 20 ℃; for 24h;

DOI:10.1021/acs.jmedchem.8b01822

upstream raw materials:

1,3-difluoro-5-methyl-2-nitrobenzene

Refernces