1,4-Dioxa-7-azaspiro[4.5]decane

Base Information

• Chemical Name: 1,4-Dioxa-7-azaspiro[4.5]decane
• CAS No.: 40369-91-3
• Molecular Formula: C7H13NO2
• Molecular Weight: 143.185
• European Community (EC) Number: 846-673-1
• DSSTox Substance ID: DTXSID80496149
• Wikidata: Q82344823
• Mol file: 40369-91-3.mol

Synonyms:1,4-Dioxa-7-azaspiro[4.5]decane;40369-91-3;1,4-DIOXA-7-AZA-SPIRO[4.5]DECANE;1,4-dioxa-9-azaspiro[4.5]decane;MFCD11858448;SCHEMBL824576;AMY6040;DTXSID80496149;FZWPOVPBHOSLFN-UHFFFAOYSA-N;BCP05243;AKOS006357492;CS-W004885;SB37061;1,4-Dioxa-7-aza-spiro [4.5] decane;BS-17028;SY105196;1 pound not4-Dioxa-7-azaspiro[4.5]decane;FT-0762529;C75044;EN300-113466;Z1203733837

Chemical Property of 1,4-Dioxa-7-azaspiro[4.5]decane

Chemical Property:

• Boiling Point: 82℃ (1 Torr)
• PKA: 8.48±0.20(Predicted)
• PSA: 30.49000
• Density: 1.12±0.1 g/cm3(Predicted)
• LogP: 0.44170
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C
• XLogP3: -0.3
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 0
• Exact Mass: 143.094628657
• Heavy Atom Count: 10
• Complexity: 121

Purity/Quality:

97% ^*data from raw suppliers

1,4-Dioxa-7-aza-spiro[4.5]decane 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1CC2(CNC1)OCCO2

Technology Process of 1,4-Dioxa-7-azaspiro[4.5]decane

There total 3 articles about 1,4-Dioxa-7-azaspiro[4.5]decane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

ethylene glycol (107-21-1) + 3-oxo-piperidine-1-carboxylic acid tert-butyl ester (98977-36-7) → 1,4-dioxa-7-azaspiro[4.5]decane (40369-91-3)

Guidance literature:

With toluene-4-sulfonic acid; In toluene; for 7h; Heating / reflux; Dean-Stark apparatus;

Reference yield:

1-Benzyl-3,3-(ethylenedioxy)piperidine (127364-04-9) → 1,4-dioxa-7-azaspiro[4.5]decane (40369-91-3)

Guidance literature:

With hydrogen; palladium on activated charcoal; In methanol;

Reference yield:

1-benzyl-3-piperidone (40114-49-6) → 1,4-dioxa-7-azaspiro[4.5]decane (40369-91-3)

Guidance literature:

Multi-step reaction with 2 steps

1: HCl / CHCl₃

2: H₂ / Pd-C / methanol

With hydrogenchloride; hydrogen; palladium on activated charcoal; In methanol; chloroform;

upstream raw materials:

1-Benzyl-3,3-(ethylenedioxy)piperidine

1-benzyl-3-piperidone

ethylene glycol

3-oxo-piperidine-1-carboxylic acid tert-butyl ester

Downstream raw materials:

1,4-dioxa-7-aza-spiro[4.5]decane-7-carboxylic acid phenethylamide

5-chloro-1H-pyrrolo[2,3-c]pyridine-2-carboxylic acid [2-(1,4-dioxa-7-aza-spiro[4,5]dec-7-yl)-1-(S)-(4-fluorobenzyl)-2-oxoethyl]amide