(3-bromo-2-fluorophenyl)methanamine hydrochloride

Base Information

• Chemical Name: (3-bromo-2-fluorophenyl)methanamine hydrochloride
• CAS No.: 1177559-63-5
• Molecular Formula: C7H7BrFN.ClH
• Molecular Weight: 240.503
• Hs Code.: 2921490090
• Mol file: 1177559-63-5.mol

Synonyms:(3-bromo-2-fluorophenyl)methanamine hydrochloride;Benzenemethanamine, 3-bromo-2-fluoro-, hydrochloride (1:1)

Chemical Property of (3-bromo-2-fluorophenyl)methanamine hydrochloride

Chemical Property:

• PSA: 26.02000
• LogP: 2.74720
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C

Purity/Quality:

98%min ^*data from raw suppliers

(3-Bromo-2-fluorophenyl)methanamineHydrochloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of (3-bromo-2-fluorophenyl)methanamine hydrochloride

There total 2 articles about (3-bromo-2-fluorophenyl)methanamine hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

3-bromo-2-fluorobenzaldehyde O-methyl oxime → (3-bromo-2-fluorophenyl)methanamine hydrochloride (1177559-63-5)

Guidance literature:

3-bromo-2-fluorobenzaldehyde O-methyl oxime; With dimethylsulfide borane complex; In tetrahydrofuran; at 0 - 80 ℃; for 5h;

With hydrogenchloride; methanol; In tetrahydrofuran; 1,4-dioxane; at 90 ℃; for 1h;

Reference yield:

3-bromo-2-fluoro-benzonitrile (840481-82-5) → (3-bromo-2-fluorophenyl)methanamine hydrochloride (1177559-63-5)

Guidance literature:

3-bromo-2-fluoro-benzonitrile; With ammonia; hydrogen; Raney-Ni; In ethanol; at 20 ℃; for 6.5h; under 760.051 Torr;

With hydrogenchloride; In water;

Reference yield:

(3-bromo-2-fluorophenyl)methanamine hydrochloride (1177559-63-5) + 3-[({[1,6-diethyl-4-(tetrahydro-2H-pyran-4-ylamino)-1H-pyrazolo[3,4-b]pyridin-5-yl]methyl}amino)carbonyl]benzoic acid (1177558-35-8) → N-[(3-bromo-2-fluorophenyl)methyl]-N'-{[1,6-diethyl-4-(tetrahydro-2H-pyran-4-ylamino)-1H-pyrazolo[3,4-b]pyridin-5-yl]methyl}-1,3-benzenedicarboxamide (1177559-62-4)

Guidance literature:

With O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; In dichloromethane; at 20 ℃; for 5h;

upstream raw materials:

3-bromo-2-fluoro-benzonitrile

Downstream raw materials:

N-[(3-bromo-2-fluorophenyl)methyl]-N'-{[1,6-diethyl-4-(tetrahydro-2H-pyran-4-ylamino)-1H-pyrazolo[3,4-b]pyridin-5-yl]methyl}-1,3-benzenedicarboxamide

Refernces

• 1、 -. "INDOLE COMPOUNDS OR ANALOGUES THEREOF USEFUL FOR THE TREATMENT OF AGE-RELATED MACULAR DEGENERATION (AMD)". Page/Page column 242. . Retrieved 2012/07/27.