4,7-DIAZA-SPIRO[2.5]OCTANE DIHYDROCHLORIDE

Base Information

• Chemical Name: 4,7-DIAZA-SPIRO[2.5]OCTANE DIHYDROCHLORIDE
• CAS No.: 145122-56-1
• Molecular Formula: C6H14Cl2N2
• Molecular Weight: 0
• Hs Code.: 2933990090
• Mol file: 145122-56-1.mol

Synonyms:4,7-Diazaspiro[2.5]octane, hydrochloride (1:2);

Chemical Property of 4,7-DIAZA-SPIRO[2.5]OCTANE DIHYDROCHLORIDE

Chemical Property:

• PSA: 24.06000
• LogP: 1.97340
• Storage Temp.: Inert atmosphere,Room Temperature

Purity/Quality:

99%, ^*data from raw suppliers

4,7-Diaza-Spiro[2.5]OctaneDihydrochloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 4,7-Diaza-spiro[2.5]octane dihydrochloride is a useful research chemical.

Technology Process of 4,7-DIAZA-SPIRO[2.5]OCTANE DIHYDROCHLORIDE

There total 4 articles about 4,7-DIAZA-SPIRO[2.5]OCTANE DIHYDROCHLORIDE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

1-(2-Benzyloxycarbonylamino-acetylamino)-cyclopropanecarboxylic acid ethyl ester (140195-93-3) → 4,7-diazaspiro<2,5>octane dihydrochloride (145122-56-1)

Guidance literature:

Multi-step reaction with 2 steps

1: H₂ / 10percent Pd/C / ethanol / 18 h / 3040 Torr

2: 1.) borane*THF complex 2.) HCl / 1.) THF, 60 deg C, 20 h 2.) methanol, reflux, 2 h

With hydrogenchloride; borane-THF; hydrogen; palladium on activated charcoal; In ethanol;

DOI:10.1139/v92-171

Reference yield:

[(1-benzyloxycarbonylaminocyclopropanecarbonyl)amino]acetic acid ethyl ester (145122-59-4) → 4,7-diazaspiro<2,5>octane dihydrochloride (145122-56-1)

Guidance literature:

Multi-step reaction with 3 steps

1: H₂ / 10percent Pd/C / ethyl acetate / 18 h / 3040 Torr

2: DBU / toluene / 22 h / 115 °C

3: 1.) borane*THF complex 2.) HCl / 1.) THF, 60 deg C, 20 h 2.) methanol, reflux, 2 h

With hydrogenchloride; borane-THF; hydrogen; 1,8-diazabicyclo[5.4.0]undec-7-ene; palladium on activated charcoal; In ethyl acetate; toluene;

DOI:10.1139/v92-171

Reference yield:

[(1-Amino-cyclopropanecarbonyl)-amino]-acetic acid ethyl ester (129306-16-7) → 4,7-diazaspiro<2,5>octane dihydrochloride (145122-56-1)

Guidance literature:

Multi-step reaction with 2 steps

1: DBU / toluene / 22 h / 115 °C

2: 1.) borane*THF complex 2.) HCl / 1.) THF, 60 deg C, 20 h 2.) methanol, reflux, 2 h

With hydrogenchloride; borane-THF; 1,8-diazabicyclo[5.4.0]undec-7-ene; In toluene;

DOI:10.1139/v92-171

upstream raw materials:

4,7-diazaspiro[2.5]octane-5,8-dione

1-(2-Benzyloxycarbonylamino-acetylamino)-cyclopropanecarboxylic acid ethyl ester

[(1-Amino-cyclopropanecarbonyl)-amino]-acetic acid ethyl ester

[(1-benzyloxycarbonylaminocyclopropanecarbonyl)amino]acetic acid ethyl ester

Downstream raw materials:

ethyl 1-(2,4-difluorophenyl)-6-fluoro-7-(4,7-diazaspiro<2,5>octan-7-yl)-1,4-dihydro-4-oxo<1,8>naphthyridine-3-carboxylate

7-(4,7-diazaspiro[2.5]octan-7-yl)-2-(2,8-dimethylimidazo[l,2- b]pyridazin-6-yl)-4H-pyrido[l,2-a]pyrimidin-4-one

1-(2,4-difluorophenyl)-6-fluoro-7-(4,7-diazaspiro<2,5>octan-7-yl)-1,4-dihydro-4-oxo<1,8>naphthyridine-3-carboxylic acid trifluoroacetic acid salt

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