(2-Chlorophenyl)methanamine hydrochloride

Base Information

• Chemical Name: (2-Chlorophenyl)methanamine hydrochloride
• CAS No.: 22680-44-0
• Molecular Formula: C5H7Cl2N3
• Molecular Weight: 178.061
• Hs Code.: 2921499090
• European Community (EC) Number: 935-245-0
• DSSTox Substance ID: DTXSID20595448
• Mol file: 22680-44-0.mol

Synonyms:(2-Chlorophenyl)methanamine hydrochloride;22680-44-0;2-CHLOROBENZYLAMINE HYDROCHLORIDE;C7H9Cl2N;(2-chlorophenyl)methanamine;hydrochloride;Benzenemethanamine, 2-chloro-, hydrochloride;Ticlopidine Hydrochloride Imp. C (EP);Ticlopidine Imp. C (EP);(2-Chlorophenyl)methanamine Hydrochloride;Ticlopidine Hydrochloride Imp. C (EP) as Hydrochloride;Ticlopidine Hydrochloride Impurity C as Hydrochloride;Ticlopidine Impurity C as Hydrochloride;(2-CHLOROPHENYL)METHANAMINE HCL;(2-Chlorophenyl)methanaminehydrochloride;(2-chlorophenyl)methanamine,hydrochloride;SCHEMBL4739133;o-chlorobenzylamine hydrochloride;DTXSID20595448;LXFIZCSCVYTFBU-UHFFFAOYSA-N;MFCD07375438;AKOS015998724;AS-18215;CS-0156647;F11177;A878473;1-(2-Chlorophenyl)methanamine--hydrogen chloride (1/1);3-Chloropyrazin-2-methanamine hydrochloride;2-Aminomethyl-3-chloropyrazine hydrochloride

Chemical Property of (2-Chlorophenyl)methanamine hydrochloride

Chemical Property:

• PSA: 51.80000
• LogP: 2.09100
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 1
• Rotatable Bond Count: 1
• Exact Mass: 177.0112047
• Heavy Atom Count: 10
• Complexity: 85

Purity/Quality:

97% ^*data from raw suppliers

(2-Chlorophenyl)methanaminehydrochloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC=C(C(=C1)CN)Cl.Cl

Technology Process of (2-Chlorophenyl)methanamine hydrochloride

There total 6 articles about (2-Chlorophenyl)methanamine hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

2-Chlorobenzonitrile (873-32-5) → (2-chlorophenyl)methanamine monohydrochloride (22680-44-0)

Guidance literature:

2-Chlorobenzonitrile; With [2,6-η6:η1-bis(2,4,6-trimethylphenyl)phenylthiolato]triethylphosphineruthenium(II)tetrakis[3,5-bis(trifluoromethyl)phenyl]borate; diethylphenylsilane; at 20 ℃; for 18h; Glovebox; Inert atmosphere;

With hydrogenchloride; In diethyl ether; at 20 ℃; for 1h; Glovebox; Inert atmosphere;

DOI:10.1055/s-0036-1588441

Reference yield: 86.0%

1-(2-chlorobenzyl)-3,4-diphenyl-1H-pyrrole-2,5-dione → (2-chlorophenyl)methanamine monohydrochloride (22680-44-0)

Guidance literature:

1-(2-chlorobenzyl)-3,4-diphenyl-1H-pyrrole-2,5-dione; With water; sodium hydroxide; In ethanol; at 105 ℃; for 0.133333h; Microwave irradiation;

With hydrogenchloride;

Reference yield: 84.0%

2-chlorobenzamide (609-66-5) → (2-chlorophenyl)methanamine monohydrochloride (22680-44-0)

Guidance literature:

2-chlorobenzamide; With [(aNHC)KN(SiMe₃)₂]₂; 4,4,5,5-tetramethyl-[1,3,2]-dioxaboralane; In toluene; at 40 ℃; for 12h; Inert atmosphere; Glovebox; Schlenk technique;

With water; sodium hydroxide; In diethyl ether; toluene; at 40 ℃; for 1h; Inert atmosphere; Glovebox; Schlenk technique;

With hydrogenchloride; In diethyl ether; water; Inert atmosphere; Glovebox; Schlenk technique;

DOI:10.1039/c9sc05953a

upstream raw materials:

2-Chlorobenzonitrile

2-CHLOROBENZYLAMINE

2-chlorobenzamide

2-chloro-benzaldehyde

Downstream raw materials:

1-(2-chlorophenyl)methylurea

(1-methyl-1H-imidazol-5-yl)methanol

5-Hydroxymethyl-1-(2-chlorobenzyl)imidazole

1-(2-chlorophenyl)methyl-2-propyl-2-thiopseudourea