2-Chloro-3,5-diiodo-4-pyridinamine

Base Information

• Chemical Name: 2-Chloro-3,5-diiodo-4-pyridinamine
• CAS No.: 1171919-00-8
• Molecular Formula: C5H3ClI2N2
• Molecular Weight: 380.35266
• Hs Code.: 2933399090
• Mol file: 1171919-00-8.mol

Synonyms:2-Chloro-3,5-diiodo-4-pyridinamine

Chemical Property of 2-Chloro-3,5-diiodo-4-pyridinamine

Chemical Property:

• Melting Point: 158-159°
• PSA: 38.91000
• LogP: 3.10760
• Storage Temp.: 2-8°C(protect from light)

Purity/Quality:

98%,99%, ^*data from raw suppliers

2-Chloro-3,5-diiodopyridin-4-amine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-Chloro-3,5-diiodo-4-pyridinamine

There total 2 articles about 2-Chloro-3,5-diiodo-4-pyridinamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 49.7%

4-Amino-2-chloropyridine (14432-12-3) → 2-chloro-4-amino-5-iodopyridine (800402-12-4) + 2-chloro-3-iodo-pyridin-4-ylamine (909036-46-0) + 2-chloro-3,5-diiodopyridin-4-amine (1171919-00-8)

Guidance literature:

With potassium acetate; Iodine monochloride; In acetic acid; at 70 ℃; for 4h; Inert atmosphere;

DOI:10.1016/j.ejmech.2014.03.019

Reference yield: 45.0%

4-Amino-2-chloropyridine (14432-12-3) → 2-chloro-4-amino-5-iodopyridine (800402-12-4) + 2-chloro-3,5-diiodopyridin-4-amine (1171919-00-8)

Guidance literature:

With sodium acetate; Iodine monochloride; acetic acid; at 60 ℃; for 2h;

DOI:10.1021/acs.jmedchem.5b01545

upstream raw materials:

4-Amino-2-chloropyridine

Refernces

• 1、 Jose, Gilish,Suresha Kumara, Tholappanavara H.,Sowmya, Haliwana B.V.,Sriram, Dharmarajan,Guru Row, Tayur N.,Hosamani, Amar A.,More, Sunil S.,Janardhan, Bhavya,Harish,Telkar, Sandeep,Ravikumar, Yalegara Siddappa. "Synthesis, molecular docking, antimycobacterial and antimicrobial evaluation of new pyrrolo[3,2-c]pyridine Mannich bases". . p. 275 - 288. Retrieved 2017.
• 2、 Jose, Gilish,Suresha Kumara,Nagendrappa, Gopalpur,Sowmya,Jasinski, Jerry P.,Millikan, Sean P.,Chandrika,More, Sunil S.,Harish. "New polyfunctional imidazo[4,5-C]pyridine motifs: Synthesis, crystal studies, docking studies and antimicrobial evaluation". . p. 288 - 297. Retrieved 2014/04/03.