tert-Butyl 1-(4-aMinophenyl)cyclobutylcarbaMate

Base Information

• Chemical Name: tert-Butyl 1-(4-aMinophenyl)cyclobutylcarbaMate
• CAS No.: 1259224-00-4
• Molecular Formula: C15H22N2O2
• Molecular Weight: 262.352
• Hs Code.: 2924299090
• Mol file: 1259224-00-4.mol

Synonyms:tert-Butyl 1-(4-aMinophenyl)cyclobutylcarbaMate;tert-butyl N-[1-(4-aMinophenyl)cyclobutyl]carbaMate

Chemical Property of tert-Butyl 1-(4-aMinophenyl)cyclobutylcarbaMate

Chemical Property:

• Boiling Point: 416.7±34.0 °C(Predicted)
• PKA: 12.78±0.20(Predicted)
• PSA: 67.84000
• Density: 1.12±0.1 g/cm3 (20 oC 760 Torr)
• LogP: 3.95830
• Storage Temp.: Keep in dark place,Inert atmosphere,Store in freezer, under -20°C

Purity/Quality:

97% ^*data from raw suppliers

tert-Butyl(1-(4-aminophenyl)cyclobutyl)carbamate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of tert-Butyl 1-(4-aMinophenyl)cyclobutylcarbaMate

There total 11 articles about tert-Butyl 1-(4-aMinophenyl)cyclobutylcarbaMate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

C23H28N2O4 → [1-(4-amino-phenyl)-cyclobutyl]-carbamic acid tert-butyl ester (1259224-00-4)

Guidance literature:

With palladium 10% on activated carbon; hydrogen; In methanol; ethyl acetate; at 20 ℃;

Reference yield: 91.6%

tert-butyl (1-(4-nitrophenyl)cyclobutyl)carbamate (1359656-25-9) → [1-(4-amino-phenyl)-cyclobutyl]-carbamic acid tert-butyl ester (1259224-00-4)

Guidance literature:

With 5%-palladium/activated carbon; hydrogen; In methanol; ethanol; n-heptane; at 20 ℃; for 6h; under 2327.23 - 2585.81 Torr;

Reference yield:

phenylacetonitrile (140-29-4) → [1-(4-amino-phenyl)-cyclobutyl]-carbamic acid tert-butyl ester (1259224-00-4)

Guidance literature:

Multi-step reaction with 4 steps

1: potassium hydroxide; tetrabutylammomium bromide / toluene; water / 1 h / Reflux

2: potassium nitrate; sulfuric acid / 20 °C

3: lead(IV) tetraacetate / 1.5 h / 80 °C

4: 5%-palladium/activated carbon; hydrogen / ethanol; methanol; n-heptane / 6 h / 20 °C / 2327.23 - 2585.81 Torr

With sulfuric acid; 5%-palladium/activated carbon; tetrabutylammomium bromide; hydrogen; lead(IV) tetraacetate; potassium nitrate; potassium hydroxide; In methanol; ethanol; n-heptane; water; toluene;

upstream raw materials:

phenylacetonitrile

1-phenylcyclobutanecarbonitrile

1-(4-nitrophenyl)cyclobutanecarbonitrile

1-(4-nitrophenyl)cyclobutanecarboxylic acid

Downstream raw materials:

tert-butyl (1-(4-((3-nitro-6-phenylpyridin-2-yl)amino)phenyl)cyclobutyl)carbamate

tert-butyl (1-(4-(2-(2-aminopyridin-3-yl)-5-phenyl-3H-imidazo[4,5-b]pyridin-3-yl)phenyl)cyclobutyl)carbamate

3-(3-(4-(1-aminocyclobutyl)phenyl)-5-phenyl-3H-imidazo[4,5-b]pyridin-2-yl)pyridin-2-amine

N-(1-(4-(2-(2-aminopyridin-3-yl)-5-phenyl-3H-imidazo[4,5-b]pyridin-3-yl)phenyl)cyclobutyl)acetamide

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