1-(4-NITROPHENYL)CYCLOBUTANECARBOXYLIC ACID

Base Information

• Chemical Name: 1-(4-NITROPHENYL)CYCLOBUTANECARBOXYLIC ACID
• CAS No.: 202737-42-6
• Molecular Formula: C11H11NO4
• Molecular Weight: 221.213
• Hs Code.: 2916399090
• Mol file: 202737-42-6.mol

Synonyms:1-(p-nitrophenyl)cyclobutanecarboxylic acid;1-(4-Nitrophenyl)cyclobutanecarboxylic acid;

Chemical Property of 1-(4-NITROPHENYL)CYCLOBUTANECARBOXYLIC ACID

Chemical Property:

• PSA: 83.12000
• LogP: 2.62430

Purity/Quality:

97% ^*data from raw suppliers

1-(4-Nitrophenyl)cyclobutanecarboxylicAcid ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1-(4-NITROPHENYL)CYCLOBUTANECARBOXYLIC ACID

There total 11 articles about 1-(4-NITROPHENYL)CYCLOBUTANECARBOXYLIC ACID which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

C11H12N2O3 → 1-(4-nitrophenyl)cyclobutanecarboxylic acid (202737-42-6)

Guidance literature:

With sodium hydroxide; In ethanol; at 60 ℃; for 17h;

Reference yield:

1-(phenyl)cyclobutane-1-carboxylic acid (37828-19-6) → 1-(4-nitrophenyl)cyclobutanecarboxylic acid (202737-42-6)

Guidance literature:

With sulfuric acid; nitric acid; In acetic anhydride; at 10 ℃; for 3h; Yield given;

DOI:10.1021/jo970211v

Reference yield:

ethyl 1-(4-nitrophenyl)cyclobutanecarboxylate → 1-(4-nitrophenyl)cyclobutanecarboxylic acid (202737-42-6)

Guidance literature:

With water; lithium hydroxide; In tetrahydrofuran; ethanol; at 20 ℃; for 20h;

upstream raw materials:

1-(phenyl)cyclobutane-1-carboxylic acid

ETHYL 4-NITROPHENYLACETATE

1-(4-nitrophenyl)cyclobutanecarbonitrile

phenylacetonitrile

Downstream raw materials:

1-(4-nitro-phenyl)-cyclobutanecarboxylic acid (2,2-dimethoxy-ethyl)-amide

tert-butyl(1-(4-((3-amino-6-phenylpyridin-2-yl)amino)phenyl)cyclobutyl)carbamate

[1-(4-amino-phenyl)-cyclobutyl]-carbamic acid tert-butyl ester

tert-butyl (1-(4-((3-nitro-6-phenylpyridin-2-yl)amino)phenyl)cyclobutyl)carbamate

Refernces

• 1、 Abeywickrema, Pravien,Andrews, Christine,Augustin, Martin,Bennett, David Jonathan,Cheng, Mangeng,Cowley, Phillip,Curran, Patrick,Fradera, Xavier,Geda, Prasanthi,Han, Yongxin,Heo, Mee Ra,Joshi, Elizabeth M.,Knemeyer, Ian,Lesburg, Charles A.,Lim, Jongwon,McGowan, Meredeth A.,Miller, J. Richard,Nickbarg, Elliott B.,Otte, Karin,Sciammetta, Nunzio,Smotrov, Nadya,Song, Xuelei,Spacciapoli, Peter,Trewick, Sarah,Von K?enig, Konstanze,White, Catherine,Woo, Hyun,Yu, Wensheng,Zhou, Hua. "Strategic Incorporation of Polarity in Heme-Displacing Inhibitors of Indoleamine-2,3-dioxygenase-1 (IDO1)". supporting information. p. 550 - 557. Retrieved 2020/04/30.
• 2、 -. "NOVEL SUBSTITUTED CYCLOBUTYLBENZENE COMPOUNDS AS INDOLEAMINE 2,3-DIOXYGENASE (IDO) INHIBITORS". . . Retrieved 2019/05/02.