TERT-BUTYL-(3-{2-[1-(2-IODO-1-METHYL-ETHYL)-7A-METHYL-OCTAHYDRO-INDEN-4-YLIDENE]-ETHYLIDENE}-4-METHYLENE-CYCLOHEXYLOXY)-DIMETHYL-SILANE

Base Information

Chemical Name:TERT-BUTYL-(3-{2-[1-(2-IODO-1-METHYL-ETHYL)-7A-METHYL-OCTAHYDRO-INDEN-4-YLIDENE]-ETHYLIDENE}-4-METHYLENE-CYCLOHEXYLOXY)-DIMETHYL-SILANE
CAS No.:170081-45-5
Molecular Formula:C28H47IOSi
Molecular Weight:554.671
Hs Code.:
Mol file:170081-45-5.mol

Synonyms:tert-Butyl-(3-{2-[1-(2-iodo-1-methyl-ethyl)-7a-methyl-octahydro-inden- 4-ylidene]-ethylidene}-4-methylene-cyclohexyloxy)-dimethyl-silane;{[(1S,3E)-3-{2-[(1R,4E,7Ar)-1-[(2S)-1-iodopropan-2-yl]-7A-methyl-octahydro-1H-inden-4-ylidene]ethylidene}-4-methylidenecyclohexyl] oxy}(tert-butyl)dimethylsilane;Silane, (1,1-dimethylethyl)dimethyl[[(1S,3E)-4-methylene-3-[(2E)-[(1R,3aS,7aR)-octahydro-1-[(1S)-2-iodo-1-methylethyl]-7a-methyl-4H-inden-4-ylidene]ethylidene]cyclohexyl]oxy]- (9CI)

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Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of TERT-BUTYL-(3-{2-[1-(2-IODO-1-METHYL-ETHYL)-7A-METHYL-OCTAHYDRO-INDEN-4-YLIDENE]-ETHYLIDENE}-4-METHYLENE-CYCLOHEXYLOXY)-DIMETHYL-SILANE

Chemical Property:

PSA：9.23000
LogP:9.25720

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of TERT-BUTYL-(3-{2-[1-(2-IODO-1-METHYL-ETHYL)-7A-METHYL-OCTAHYDRO-INDEN-4-YLIDENE]-ETHYLIDENE}-4-METHYLENE-CYCLOHEXYLOXY)-DIMETHYL-SILANE

There total 11 articles about TERT-BUTYL-(3-{2-[1-(2-IODO-1-METHYL-ETHYL)-7A-METHYL-OCTAHYDRO-INDEN-4-YLIDENE]-ETHYLIDENE}-4-METHYLENE-CYCLOHEXYLOXY)-DIMETHYL-SILANE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.5%

: 344798-32-9
3(S)-<(tert-butyldimethylsilyl)oxy>-20(S)-(iodomethyl)-9,10-secopregna-5(Z),7(E),10(19)-triene SO2 adduct

: 170081-45-5
3(S)-<(tert-butyldimethylsilyl)oxy>-20(S)-(iodomethyl)-9,10-secopregna-5(E),7(E),10(19)-triene

Guidance literature:: With sodium hydrogencarbonate; In ethanol; for 2h; Heating;
DOI:10.1021/jo00125a051

Reference yield: 71.0%

: C₂₈H₄₈O₄SSi

: 170081-45-5
3(S)-<(tert-butyldimethylsilyl)oxy>-20(S)-(iodomethyl)-9,10-secopregna-5(E),7(E),10(19)-triene

Guidance literature:: C₂₈H₄₈O₄SSi; With 1H-imidazole; iodine; triphenylphosphine; In dichloromethane; at 20 ℃; for 3h;

With sodium hydrogencarbonate; In ethanol; at 90 ℃; for 2h;

Reference yield:

: 170081-43-3,251445-16-6
SO2-adduct of 3(S)-<(tert-butyldimethylsilyl)oxy>-9,10-secoergosta-5,7(E),10(19),22(E)-tetraene

: 170081-45-5
3(S)-<(tert-butyldimethylsilyl)oxy>-20(S)-(iodomethyl)-9,10-secopregna-5(E),7(E),10(19)-triene

Guidance literature:: Multi-step reaction with 3 steps

1: 1.) O₃, 2.) NaBH₄ / 1.) CH₂Cl₂, MeOH, -10 deg C, 2.) room temperature, 2 h

2: 71 percent / I₂, PPh₃, imidazole / CH₂Cl₂ / 1.) 5 deg C, 0.5 h, 2.) room temperature, 2.0 h

3: 92.5 percent / NaHCO₃ / ethanol / 2 h / Heating

With 1H-imidazole; sodium tetrahydroborate; iodine; sodium hydrogencarbonate; ozone; triphenylphosphine; In ethanol; dichloromethane;
DOI:10.1021/jo00125a051