(2R,4R)-2-hydroxymethyl-4-CBZ-amino Pyrrolidine-HCl

Base Information

Chemical Name:(2R,4R)-2-hydroxymethyl-4-CBZ-amino Pyrrolidine-HCl
CAS No.:1217692-66-4
Molecular Formula:C13H19ClN2O3
Molecular Weight:286.76098
Hs Code.:
Mol file:1217692-66-4.mol

Synonyms:Benzyl ((3R,5R);pyrrolidin-3-yl);(2R,4R)-2-hydroxyMethyl-4-CBZ-aMino Pyrrolidine-HCl;(2R,4R)-2-hydroxymethyl-4-cbz-amino pyrrolidine Hydrochloride;Benzyl ((3R,5R)-5-(hydroxyMethyl)pyrrolidin-3-yl)carbaMate hydrochloride;Benzyl ((3R,5R)-rel-5-(hydroxymethyl)pyrrolidin-3-yl)carbamate hydrochloride

Suppliers and Price of (2R,4R)-2-hydroxymethyl-4-CBZ-amino Pyrrolidine-HCl

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
(2R,4R)-2-hydroxymethyl-4-cbz-aminopyrrolidineHydrochloride
50mg
$ 220.00

TRC
(2R,4R)-2-hydroxymethyl-4-cbz-aminopyrrolidineHydrochloride
10mg
$ 65.00

Crysdot
Benzyl((3R,5R)-5-(hydroxymethyl)pyrrolidin-3-yl)carbamatehydrochloride 95+%
250mg
$ 473.00

Crysdot
Benzyl((3R,5R)-5-(hydroxymethyl)pyrrolidin-3-yl)carbamatehydrochloride 95+%
1g
$ 1186.00

Chemenu
benzyl((3R,5R)-5-(hydroxymethyl)pyrrolidin-3-yl)carbamatehydrochloride 95%
1g
$ 1117.00

American Custom Chemicals Corporation
BENZYL-((3R,5R)-5-(HYDROXYMETHYL)PYRROLIDIN-3-YL)CARBAMATE HYDROCHLORIDE 95.00%
1G
$ 2355.15

Alichem
Benzyl((3R,5R)-5-(hydroxymethyl)pyrrolidin-3-yl)carbamatehydrochloride
1g
$ 1008.00

Alichem
Benzyl((3R,5R)-5-(hydroxymethyl)pyrrolidin-3-yl)carbamatehydrochloride
250mg
$ 473.22

Total 12 raw suppliers

Chemical Property of (2R,4R)-2-hydroxymethyl-4-CBZ-amino Pyrrolidine-HCl

Chemical Property:

Storage Temp.:Sealed in dry,Room Temperature

Purity/Quality:

97% ^*data from raw suppliers

(2R,4R)-2-hydroxymethyl-4-cbz-aminopyrrolidineHydrochloride ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of (2R,4R)-2-hydroxymethyl-4-CBZ-amino Pyrrolidine-HCl

There total 2 articles about (2R,4R)-2-hydroxymethyl-4-CBZ-amino Pyrrolidine-HCl which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

: 1194057-63-0,1932593-75-3
(2S,4R)-tert-butyl 4-(benzyloxycarbonylamino)-2-(hydroxymethyl)pyrrolidine-1-carboxylate

: 1194057-62-9,1217692-66-4
benzyl ((3R,5S)-5-(hydroxymethyl)pyrrolidin-3-yl)carbamate hydrochloride

Guidance literature:: With hydrogenchloride; In 1,4-dioxane; diethyl ether; at 20 ℃;

Reference yield:

: 1217692-66-4
benzyl [(3R,5R)-5-(hydroxymethyl)pyrrolidin-3-yl]carbamate hydrochloride

Guidance literature:: With hydrogenchloride; In 1,4-dioxane; methanol; at 20 ℃; for 1h;

Reference yield:

: 1194057-62-9,1217692-66-4
benzyl ((3R,5S)-5-(hydroxymethyl)pyrrolidin-3-yl)carbamate hydrochloride

: 1194057-67-4
ethyl (3aS,5R)-5-benzyloxycarbonylamino-13-cyclopropyl-8-fluoro-10-oxo-3a,4,5,6,10,13-hexahydro-1H,3H-pyrrolo[2',1':3,4][1,4]oxazepino[5,6-h]quinoline-11-carboxylate

Guidance literature:: Multi-step reaction with 3 steps

1.1: N-ethyl-N,N-diisopropylamine / acetonitrile / 2 h / 50 °C / Inert atmosphere

2.1: sodium tris(acetoxy)borohydride / dichloromethane / 120 h / 20 °C / Inert atmosphere

2.2: Inert atmosphere

3.1: boron trifluoride diethyl etherate / dichloromethane / 18 h / -40 - 20 °C / Inert atmosphere

With boron trifluoride diethyl etherate; sodium tris(acetoxy)borohydride; N-ethyl-N,N-diisopropylamine; In dichloromethane; acetonitrile;