3-(2-Difluoromethoxy-phenyl)-acrylic acid

Base Information

Chemical Name:3-(2-Difluoromethoxy-phenyl)-acrylic acid
CAS No.:127842-71-1
Molecular Formula:C10H8F2O3
Molecular Weight:214.169
Hs Code.:
European Community (EC) Number:879-318-4
Mol file:127842-71-1.mol

Synonyms:127842-71-1;3-[2-(difluoromethoxy)phenyl]acrylic acid;(2E)-3-[2-(difluoromethoxy)phenyl]prop-2-enoic acid;(E)-3-[2-(difluoromethoxy)phenyl]prop-2-enoic acid;884-05-9;3-[2-(difluoromethoxy)phenyl]prop-2-enoic Acid;MFCD03419433;3-(2-Difluoromethoxy-phenyl)-acrylic acid;(E)-3-(2-(Difluoromethoxy)phenyl)acrylic acid;(2E)-3-[2-(DIFLUOROMETHOXY)PHENYL]ACRYLIC ACID;2-Propenoic acid, 3-[2-(difluoromethoxy)phenyl]-, (E)- (9CI);3-(2-(DIFLUOROMETHOXY)PHENYL)ACRYLIC ACID;SCHEMBL1536373;2-(Difluoromethoxy)cinnamic acid;BBL038241;STK301551;AKOS000200533;CS-0262598;EN300-26446;EN300-832931;Z2942851934

Suppliers and Price of 3-(2-Difluoromethoxy-phenyl)-acrylic acid

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

American Custom Chemicals Corporation
3-(2-DIFLUOROMETHOXY-PHENYL)-ACRYLIC ACID 95.00%
5G
$ 1143.68

American Custom Chemicals Corporation
3-(2-DIFLUOROMETHOXY-PHENYL)-ACRYLIC ACID 95.00%
2.5G
$ 958.94

American Custom Chemicals Corporation
3-(2-DIFLUOROMETHOXY-PHENYL)-ACRYLIC ACID 95.00%
1G
$ 707.02

Total 4 raw suppliers

Chemical Property of 3-(2-Difluoromethoxy-phenyl)-acrylic acid

Chemical Property:

Vapor Pressure:0.000142mmHg at 25°C
Boiling Point:319.4°C at 760 mmHg
Flash Point:147°C
PSA：46.53000
Density:1.335g/cm³
LogP:2.38580
XLogP3:2.8
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:4
Exact Mass:214.04415044
Heavy Atom Count:15
Complexity:241

Purity/Quality:

99%+ ^*data from raw suppliers

3-(2-DIFLUOROMETHOXY-PHENYL)-ACRYLIC ACID 95.00% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1=CC=C(C(=C1)C=CC(=O)O)OC(F)F
Isomeric SMILES:C1=CC=C(C(=C1)/C=C/C(=O)O)OC(F)F

Technology Process of 3-(2-Difluoromethoxy-phenyl)-acrylic acid

There total 2 articles about 3-(2-Difluoromethoxy-phenyl)-acrylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 40.0%

: 141-82-2
malonic acid

: 71653-64-0
o-difluoromethoxybenzaldehyde

: 127842-71-1
2-difluoromethoxycinnamic acid

: 127842-69-7
3-(2-difluoromethoxyphenyl)-3-aminopropionic acid

Guidance literature:: With ammonium acetate; In ethanol; for 4h; Heating;

Reference yield:

: 141-82-2
malonic acid

: 71653-64-0
o-difluoromethoxybenzaldehyde

: 127842-71-1
2-difluoromethoxycinnamic acid

Guidance literature:: With piperidine; pyridine; at 90 ℃; Inert atmosphere;
DOI:10.1016/j.bmc.2017.08.047

Reference yield: 100.0%

: 127842-71-1
2-difluoromethoxycinnamic acid

: C₁₀H₇ClF₂O₂

Guidance literature:: With thionyl chloride; In dichloromethane; N,N-dimethyl-formamide; Reflux; Inert atmosphere;
DOI:10.1016/j.bmc.2017.08.047