71653-64-0

Basic information

• Product Name: 2-(DIFLUOROMETHOXY)BENZALDEHYDE
• Synonyms: 2-(Difluoromethoxy)benzaldehyde, 97+%;2-(Difluoromethoxy)benzaldehyde 97%;4-n-butyryl biphenyl ;2-difloroMethoxybenzaldehyde;TIMTEC-BB SBB003836;O-DIFLUOROMETHOXYBENZALDEHYDE;AKOS B006818;2-(DIFLUOROMETHOXY)BENZALDEHYDE
• CAS NO: 71653-64-0
• Molecular Formula: C₈H₆F₂O₂
• Molecular Weight: 172.13
• Product Categories: Benzaldehyde;Aldehyde;Organoborons;Pyridine;Thiophene;Aldehydes;C8;Carbonyl Compounds;Fluorine series
• Mol File: 71653-64-0.mol
• Article Data: 6

Chemical Properties

• Boiling Point: 216 °C(lit.)
• Flash Point: 224 °F
• Appearance: /
• Density: 1.3 g/mL at 25 °C(lit.)
• Vapor Pressure: 0.000114mmHg at 25°C
• Refractive Index: n20/D 1.497(lit.)
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C
• Solubility: Miscible with 2-propanol and acetic acid.
• Sensitive: Air Sensitive
• BRN: 389068
• CAS DataBase Reference: 2-(DIFLUOROMETHOXY)BENZALDEHYDE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(DIFLUOROMETHOXY)BENZALDEHYDE(71653-64-0)
• EPA Substance Registry System: 2-(DIFLUOROMETHOXY)BENZALDEHYDE(71653-64-0)

Safety Data

• Hazard Codes: Xi
• Statements: 20/21/22-36/38-36/37/38
• Safety Statements: 26-36-37/39-37
• WGK Germany: 3
• RTECS: CU5615600
• HazardClass: IRRITANT
• Hazardous Substances Data: 71653-64-0(Hazardous Substances Data)

Usage

Uses

Different sources of media describe the Uses of 71653-64-0 differently. You can refer to the following data:
1. 2-(Difluoromethoxy)benzaldehyde is an important raw material used as an intermediate in the preparation of pharmaceuticals, agrochemicals, and dyestuffs. It is also involved in the preparation of 4-(2-difluoromethoxyphenyl)- substituted 1,4-dihydropyridine 3,5-diesters.
2. 2-(Difluoromethoxy)benzaldehyde may be used as a starting reagent in the synthesis of the following compounds:2-[2-(difluoromethoxy)benzylidene]methyl acetoacetate3-(2-cyanoethyl) 5-(2-propoxyethyl) 4-[2-(difluoromethoxy)phenyl]-2,6-dimethyl-1,4-dihydro-3,5-pyridinedicarboxylate2-propoxyethyl 5-cyano-4-[2-(difluoromethoxy)phenyl]-2-methyl-6-thioxo-1,4,5,6-tetrahydropyridine-3-carboxylatemethyl 5-cyano-4-(2-difluoromethoxyphenyl)-2-methyl-6-thioxo-1,4,5,6-tetrahydropyridine-3-carboxylate

General Description

2-(Difluoromethoxy)benzaldehyde is an ortho-difluoromethoxy substituted benzaldehyde.

InChI:InChI=1/C9H6F3NOS/c10-9(11,12)5-1-2-7-6(3-5)13-8(14)4-15-7/h1-3H,4H2,(H,13,14)

Upstream product

• 90-02-8 salicylaldehyde 
• 75-45-6 Chlorodifluoromethane 
• 115262-01-6 [bromo(difluoro)methyl]-trimethyl-silane 

Downstream Products

• 121112-80-9 4-(2-Difluoromethoxy-phenyl)-6-methyl-2-thioxo-1,2,3,4-tetrahydro-pyrimidine-5-carboxylic acid ethyl ester 
• 112024-97-2 4-(2-Difluoromethoxy-phenyl)-6-methyl-2-oxo-1,2,3,4-tetrahydro-pyrimidine-5-carboxylic acid ethyl ester 
• 121112-81-0 4-(2-Difluoromethoxy-phenyl)-6-methyl-1-phenyl-2-thioxo-1,2,3,4-tetrahydro-pyrimidine-5-carboxylic acid ethyl ester 
• 84761-70-6 2,6-dimethyl-3,5-diethoxycarbonyl-4-(-o-difluoromethoxyphenyl)-1,4-dihydropyridine 
• 117631-98-8 4-(2-Difluoromethoxy-phenyl)-2,6-dimethyl-1,4-dihydro-pyridine-3,5-dicarboxylic acid di-tert-butyl ester 
• 127842-71-1 2-difluoromethoxycinnamic acid 
• 127842-69-7 3-(2-difluoromethoxyphenyl)-3-aminopropionic acid 
• 110544-06-4 2,6-Dimethyl-3,5-dipropoxycarbonyl-4-(o-difluoromethoxyphenyl)-1,4-dihydropyridine 
• 110544-72-4 4-(2-Difluoromethoxy-phenyl)-2,6-dimethyl-1,4-dihydro-pyridine-3,5-dicarboxylic acid diisobutyl ester 
• 117654-52-1 4-(2-Difluoromethoxy-phenyl)-2,6-dimethyl-1,4-dihydro-pyridine-3,5-dicarboxylic acid dinonyl ester 
• 117631-99-9 4-(2-Difluoromethoxy-phenyl)-2,6-dimethyl-1,4-dihydro-pyridine-3,5-dicarboxylic acid didecyl ester 
• 117632-00-5 4-(2-Difluoromethoxy-phenyl)-2,6-dimethyl-1,4-dihydro-pyridine-3,5-dicarboxylic acid didodecyl ester 
• 108863-62-3 Cerebrocrast 
• 117654-51-0 4-(2-Difluoromethoxy-phenyl)-2,6-dimethyl-1,4-dihydro-pyridine-3,5-dicarboxylic acid bis-(2-isopropyl-5-methyl-cyclohexyl) ester 

Relevant articles and documents

SYNTHESIS OF DIFLUOROMETHYL ETHERS AND SULFIDES

The synthesis of difluoromethyl ethers and sulfides with a simple, non-ozone- depleting reagent is described. The difluoromethylation of phenols with this reagent occurs at room temperature within minutes with exceptional functional group tolerance. The mild conditions makes possible tandem processes for the conversion of aryl boronic acids, aryl halides and arenes to difluoromethyl ethers. Mechanistic studies support a reaction pathway involving nucleophilic attack of the phenolate to difluorocarbene.

Pharmaceutical uses for fluoroalkoxybenzylamino derivatives of nitrogen containing heterocycles

The present invention relates to methods of treating various CNS and other disorders by adminstering fluoroalkoxybenzylamino derivatives of nitrogen containing heterocyclic compounds, and specifically, by administering compounds of the formula wherein Q,

FLUOROALKOXYBENZYLAMINO DERIVATIVES OF NITROGEN CONTAINING HETEROCYCLES

The present invention relates to novel fluoroalkoxybenzylamino derivatives of nitrogen containing heterocyclic compounds, and specifically, to compounds of the formula STR1 wherein Q, X 1, x. sup.2 and X 3 are as defined below. These novel compounds are u