(+)-2,3-O-ISOPROPYLIDENE-D-THREITOL 1,4-DIMETHANE SULFONATE

Base Information

• Chemical Name: (+)-2,3-O-ISOPROPYLIDENE-D-THREITOL 1,4-DIMETHANE SULFONATE
• CAS No.: 109281-59-6
• Molecular Formula: C9H18O8S2
• Molecular Weight: 318.36442
• Hs Code.: 2932999099
• Mol file: 109281-59-6.mol

Synonyms:(+)-2,3-O-Isopropylidene-D-threitol-2,3-dimethanesulfonate;

Chemical Property of (+)-2,3-O-ISOPROPYLIDENE-D-THREITOL 1,4-DIMETHANE SULFONATE

Chemical Property:

• Melting Point: 95.5 - 97.5 °C (diethyl ether)
• PSA: 121.96000
• LogP: 1.62050

Purity/Quality:

98%min ^*data from raw suppliers

(+)-2,3-O-ISOPROPYLIDENE-D-THREITOL-1,4-DIMETHANE SULFONATE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of (+)-2,3-O-ISOPROPYLIDENE-D-THREITOL 1,4-DIMETHANE SULFONATE

There total 6 articles about (+)-2,3-O-ISOPROPYLIDENE-D-THREITOL 1,4-DIMETHANE SULFONATE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

(4R,5R)-2,2-dimethyl-1,3-dioxolane-4,5-dimethanol (73346-74-4) + methanesulfonyl chloride (124-63-0) → 2,3-O-isopropylidene-1,4-di-O-methanesulphonyl-D-threitol (109281-59-6)

Guidance literature:

With pyridine; In dichloromethane;

DOI:10.1002/chir.22814

Reference yield:

dimethyl 2,2-dimethyl-1,3-dioxolane-trans-4,5-dicarboxylate (116499-08-2) → 2,3-O-Isopropyliden-DL-threitol-1,4-bis-methansulfonat (4248-74-2,38279-61-7,94943-42-7,109281-59-6)

Guidance literature:

Multi-step reaction with 2 steps

1: sodium tetrahydroborate

2: triethylamine / dichloromethane

With sodium tetrahydroborate; triethylamine; In dichloromethane;

DOI:10.1039/c9sc05997k

Reference yield:

2,3-O-Isopropyliden-DL-threitol (25432-12-6,50622-09-8,55904-12-6,69460-89-5,73346-74-4,86992-57-6) + methanesulfonyl chloride (124-63-0) → 2,3-O-Isopropyliden-DL-threitol-1,4-bis-methansulfonat (4248-74-2,38279-61-7,94943-42-7,109281-59-6)

Guidance literature:

With triethylamine; In dichloromethane;

DOI:10.1039/c9sc05997k

upstream raw materials:

dimethyl 2,2-dimethyl-1,3-dioxolane-trans-4,5-dicarboxylate

2,3-O-Isopropyliden-DL-threitol

methanesulfonyl chloride

(4R,5R)-2,2-dimethyl-1,3-dioxolane-4,5-dimethanol

Downstream raw materials:

DL-Threitol-1,4-bis-methansulfonat

treosulfan