N-BOC-2-BROMOPYRROLE, IN HEXANE - 25% W/V

Base Information

• Chemical Name: N-BOC-2-BROMOPYRROLE, IN HEXANE - 25% W/V
• CAS No.: 117657-37-1
• Molecular Formula: C9H12BrNO2
• Molecular Weight: 246.104
• Hs Code.: 2933990090
• Mol file: 117657-37-1.mol

Synonyms:N-BOC-2-BROMOPYRROLE, IN HEXANE - 25% W/V;2-BroMo-1H-pyrrole-1-carboxylic Acid 1,1-DiMethylethyl Ester;tert-butyl 2-broMo-1H-pyrrole-1-carboxylate

Chemical Property of N-BOC-2-BROMOPYRROLE, IN HEXANE - 25% W/V

Chemical Property:

• Boiling Point: 279.3±32.0 °C(Predicted)
• PKA: -9.39±0.70(Predicted)
• PSA: 31.23000
• Density: 1.37±0.1 g/cm3(Predicted)
• LogP: 3.03380
• Storage Temp.: -20°C Freezer

Purity/Quality:

97% ^*data from raw suppliers

N-Boc-2-bromopyrrole,inhexane-25%w/v ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of N-BOC-2-BROMOPYRROLE, IN HEXANE - 25% W/V

There total 3 articles about N-BOC-2-BROMOPYRROLE, IN HEXANE - 25% W/V which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

tert-butyl 2-(trimethylstannyl)-1H-pyrrole-1-carboxylate → 2-bromo-pyrrole-1-carboxylic acid tert-butyl ester (117657-37-1)

Guidance literature:

With N-Bromosuccinimide; In tetrahydrofuran; at 3 ℃; for 16h;

DOI:10.1080/00397919508011772

Reference yield: 89.0%

2-bromo-1H-pyrrole (38480-28-3) + di-tert-butyl dicarbonate (24424-99-5) → 2-bromo-pyrrole-1-carboxylic acid tert-butyl ester (117657-37-1)

Guidance literature:

With dmap; triethylamine; at -78 - 20 ℃; Inert atmosphere;

DOI:10.15227/orgsyn.070.0151

Reference yield: 82.0%

pyrrole (109-97-7,30604-81-0) + di-tert-butyl dicarbonate (24424-99-5) → 2-bromo-pyrrole-1-carboxylic acid tert-butyl ester (117657-37-1)

Guidance literature:

pyrrole; With N-Bromosuccinimide; In tetrahydrofuran; at -78 - -20 ℃; for 2.08333h;

di-tert-butyl dicarbonate; With dmap; triethylamine; at -78 - 20 ℃; for 8h;

upstream raw materials:

2-bromo-1H-pyrrole

di-tert-butyl dicarbonate

pyrrole

Downstream raw materials:

tert-butyl 2-(2-methoxyphenyl)-1H-pyrrole-1-carboxylate

2-(2-methylphenyl)-1H-pyrrole-1-carboxylic acid 1,1-dimethylethyl ester

tert-butyl 2-(pyridin-3-yl)-1H-pyrrole-1-carboxylate

2-phenyl-1H-pyrrole