2-Bromo-6-methoxybenzonitrile

Base Information

• Chemical Name: 2-Bromo-6-methoxybenzonitrile
• CAS No.: 1245647-50-0
• Molecular Formula: C8H6BrNO
• Molecular Weight: 212.046
• Hs Code.: 2926909090
• Mol file: 1245647-50-0.mol

Synonyms:2-Bromo-6-methoxybenzonitrile

Chemical Property of 2-Bromo-6-methoxybenzonitrile

Chemical Property:

• Boiling Point: 310.9±27.0 °C(Predicted)
• PSA: 33.02000
• Density: 1.56±0.1 g/cm3(Predicted)
• LogP: 2.32938
• Storage Temp.: Sealed in dry,Room Temperature

Purity/Quality:

98% ^*data from raw suppliers

2-Bromo-6-methoxybenzonitrile ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-Bromo-6-methoxybenzonitrile

There total 2 articles about 2-Bromo-6-methoxybenzonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 54.0%

3-bromoveratrole (5424-43-1) + 2-hydroxy-2-methylpropanenitrile (75-86-5) → 2-bromo-6-methoxybenzonitrile (1245647-50-0)

Guidance literature:

With 3,6‐di‐tert‐butyl‐9‐mesityl‐10‐phenylacridin‐10‐ium tetrafluoroborate; sodium hydrogencarbonate; In 1,2-dichloro-ethane; at 26 ℃; for 18h; Inert atmosphere; Sealed tube; Irradiation;

DOI:10.1021/acs.orglett.9b02678

Reference yield: 50.0%

C8H8BrN3O (1393739-62-2) → 2-bromo-6-methoxybenzonitrile (1245647-50-0)

Guidance literature:

With tert.-butylhydroperoxide; [bis(acetoxy)iodo]benzene; In decane; acetonitrile; at 0 ℃; for 12h;

DOI:10.1016/j.tetlet.2012.06.131

Reference yield: 90.0%

4-(carbazol-9-yl)phenylboronic acid (419536-33-7) + 2-bromo-6-methoxybenzonitrile (1245647-50-0) → C26H18N2O

Guidance literature:

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate; In ethanol; water; toluene; at 100 ℃; for 17h; Inert atmosphere;

upstream raw materials:

C₈H₈BrN₃O

3-bromoveratrole

2-hydroxy-2-methylpropanenitrile

Refernces

• 1、 Zhao, Yi,Chew, Xinying,Leung, Gulice Y.C.,Yeung, Ying-Yeung. "Oxidative transformation of azides to aryl nitriles using DIB/TBHP: Scope and mechanistic insights". experimental part. p. 4766 - 4769. Retrieved 2012/09/07.