2-Fluoro-4-iodonitrobenzene

Base Information

• Chemical Name: 2-Fluoro-4-iodonitrobenzene
• CAS No.: 2996-31-8
• Molecular Formula: C6H3FINO2
• Molecular Weight: 266.998
• Hs Code.: 2904990090
• Mol file: 2996-31-8.mol

Synonyms:2-Fluoro-4-iodo-1-nitrobenzene; 3-Fluoro-4-nitroiodobenzene

Chemical Property of 2-Fluoro-4-iodonitrobenzene

Chemical Property:

• Melting Point: 118-119℃
• Boiling Point: 296℃
• Flash Point: 133℃
• PSA: 45.82000
• Density: 2.093
• LogP: 2.86170

Purity/Quality:

95% ^*data from raw suppliers

2-Fluoro-4-iodo-1-nitrobenzene ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-Fluoro-4-iodonitrobenzene

There total 1 articles about 2-Fluoro-4-iodonitrobenzene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

3-fluoro-4-nitroaniline (2369-13-3) → 2-fluoro-4-iodo-1-nitrobenzene (2996-31-8)

Guidance literature:

Multistep reaction; (i) NaNO₂, aq. HCl, (ii) KI, I₂;

DOI:10.1021/jo01078a015

Reference yield: 88.0%

(S)-2-(1,3-dioxoisoindolin-2-yl)-N-(quinolin-8-yl)propanamide (908129-33-9) + 2-fluoro-4-iodo-1-nitrobenzene (2996-31-8) → (S)-N-(3-(4-nitro-3-fluorophenyl)-2-phthalimidopropionyl)-8-aminoquinoline

Guidance literature:

With silver tetrafluoroborate; palladium diacetate; In 1,2-dichloro-ethane; tert-butyl alcohol; at 75 ℃; for 24h;

DOI:10.1039/c4cc06652a

Reference yield: 75.0%

N-(2-(pyridin-2-yl)propan-2-yl)butyramide + 2-fluoro-4-iodo-1-nitrobenzene (2996-31-8) → 3-(3-fluoro-4-nitrophenyl)-N-(2-(pyridin-2-yl)propan-2-yl)butanamide (1620051-28-6)

Guidance literature:

With silver(I) acetate; palladium diacetate; In tert-butyl alcohol; at 100 ℃; for 24h; Schlenk technique; Inert atmosphere;

DOI:10.1039/c4cc03615h

upstream raw materials:

3-fluoro-4-nitroaniline

Downstream raw materials:

3-(3-fluoro-4-nitrophenyl)-N-(2-(pyridin-2-yl)propan-2-yl)butanamide

Refernces