Technology Process of 4-Chloro-6-methoxy-2-hydroxy-1-nitrosoindolin-3-one oxime
There total 6 articles about 4-Chloro-6-methoxy-2-hydroxy-1-nitrosoindolin-3-one oxime which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
hydrogenchloride; sodium nitrite;
for 1h;
Heating;
pH = 2.5;
DOI:10.1021/ja00274a043
- Guidance literature:
-
Multi-step reaction with 6 steps
1: 45 percent / fuming nitric acid, fuming sulfuric acid / 6 h / 80 - 90 °C
2: 57 percent / sodium / 2 h / Heating
3: 35 percent / sodium bicarbonate, sodium sulfide nonahydrate / H2O / 1 h / Heating
4: 58 percent / 1.) sodium nitrite, 12M HCl; 2.) copper(I) chloride / H2O / 0 - 5 °C / 2.) 10 min
5: 1.) pyrrolydine; 2.) H2 / 2.) 5percent palladium on charcoal / 1.) DMF, reflux, 3 h; 2.) 4 atm
6: 15 percent / 0.05M aq. sodium nitrite, HCl / 1 h / Heating; pH = 2.5
With
pyrrolidine; hydrogenchloride; sodium sulfide; sulfuric acid; hydrogen; nitric acid; sodium; sodium hydrogencarbonate; copper(l) chloride; sodium nitrite;
palladium on activated charcoal;
In
water;
DOI:10.1021/ja00274a043
- Guidance literature:
-
Multi-step reaction with 3 steps
1: 58 percent / 1.) sodium nitrite, 12M HCl; 2.) copper(I) chloride / H2O / 0 - 5 °C / 2.) 10 min
2: 1.) pyrrolydine; 2.) H2 / 2.) 5percent palladium on charcoal / 1.) DMF, reflux, 3 h; 2.) 4 atm
3: 15 percent / 0.05M aq. sodium nitrite, HCl / 1 h / Heating; pH = 2.5
With
pyrrolidine; hydrogenchloride; hydrogen; copper(l) chloride; sodium nitrite;
palladium on activated charcoal;
In
water;
DOI:10.1021/ja00274a043
