3,3'-Diindolyl Disulphide

Base Information

• Chemical Name: 3,3'-Diindolyl Disulphide
• CAS No.: 61830-39-5
• Molecular Formula: C16H12N2S2
• Molecular Weight: 296.417
• DSSTox Substance ID: DTXSID80395128
• Wikidata: Q82194984
• Mol file: 61830-39-5.mol

Synonyms:3,3'-Diindolyl Disulphide;61830-39-5;3-(1H-indol-3-yldisulfanyl)-1H-indole;1,2-Di(1H-indol-3-yl)disulfane;di(3-indolyl) disulfide;3,3'-Diindolyl disulfide;3,3/'-Diindolyl Disulphide;SCHEMBL9328490;DTXSID80395128;AKOS030240297;FT-0667171

Chemical Property of 3,3'-Diindolyl Disulphide

Chemical Property:

• Melting Point: 218-220°C dec.
• PSA: 82.18000
• LogP: 5.44860
• Storage Temp.: -20?C Freezer
• Solubility.: DMSO (Slightly)
• XLogP3: 4.3
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 3
• Exact Mass: 296.04419074
• Heavy Atom Count: 20
• Complexity: 306

Purity/Quality:

97% ^*data from raw suppliers

3,3''-DiindolylDisulphide ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC=C2C(=C1)C(=CN2)SSC3=CNC4=CC=CC=C43

Technology Process of 3,3'-Diindolyl Disulphide

There total 6 articles about 3,3'-Diindolyl Disulphide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

indole (120-72-9) → S,S'-Bis-(3-indolyl)disulphide (61830-39-5)

Guidance literature:

With sodium hydroxide; iodine; thiourea; air; In ethanol; water; at 20 ℃;

DOI:10.1055/s-2006-950427

Reference yield:

S-(3-indolyl)isothiourea hydrogeniodide (26377-76-4) → 1H-indole-3-thiol (480-94-4) + S,S'-Bis-(3-indolyl)disulphide (61830-39-5)

Guidance literature:

With sodium hydroxide; at 80 ℃; for 0.5h;

Reference yield:

indole (120-72-9) + thiourea (17356-08-0) → S,S'-Bis-(3-indolyl)disulphide (61830-39-5)

Guidance literature:

With sodium hydroxide; iodine;

DOI:10.1021/ja01165a551

upstream raw materials:

indole

thiourea

1H-indole-3-thiol

chloroacetone

Downstream raw materials:

3,3'-dithiobis(1-phenylsulfonyl-1H-indole)

3,3'-dithiobis[1-(4-methylphenylsulfonyl)-1H-indole]

2-(1-phenylsulfonyl-1H-indol-3-yl)thio-1H-indole

5,10-dihydro[1,2,3,4]tetrathiocino[5,6-b:8,7-b']diindole

Refernces

• 1、 Yang, Yong,Li, Wanmei,Ying, Beibei,Liao, Hanxiao,Shen, Chao,Zhang, Pengfei. "Catalyst-Triggered Highly Selective C?S and C?Se Bond Formation by C?H Activation". . p. 2916 - 2919. Retrieved 2016/09/28.
• 2、 Shirani, Hamid,Stensland, Birgitta,Bergman, Jan,Janosik, Tomasz. "New routes to 3-(arylthio)indoles: Application to the synthesis of the 3,3′-bis(indoyl) sulfone core of the marine alkaloid echinosulfone A". . p. 2459 - 2463. Retrieved 2008/02/10.