ETHYL 2-[6-(METHYLAMINO)-2-PYRIDYL]ACETATE

Base Information

• Chemical Name: ETHYL 2-[6-(METHYLAMINO)-2-PYRIDYL]ACETATE
• CAS No.: 205676-86-4
• Molecular Formula: C₁₀H₁₄N₂O₂
• Molecular Weight: 194.233
• Hs Code.: 2933399090
• Mol file: 205676-86-4.mol

Synonyms:ETHYL 2-[6-(METHYLAMINO)-2-PYRIDYL]ACETATE;Ethyl 2-(6-(MethylaMino)pyridin-2-yl)acetate

Chemical Property of ETHYL 2-[6-(METHYLAMINO)-2-PYRIDYL]ACETATE

Chemical Property:

• PSA: 51.22000
• LogP: 1.30190
• Storage Temp.: 2-8°C

Purity/Quality:

97% ^*data from raw suppliers

2-PYRIDINEACETICACID,6-(METHYLAMINO)-,ETHYLESTER 95 ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of ETHYL 2-[6-(METHYLAMINO)-2-PYRIDYL]ACETATE

There total 5 articles about ETHYL 2-[6-(METHYLAMINO)-2-PYRIDYL]ACETATE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

ethyl 2-{6-[(tert-butoxy)-N-methylcarbonylamino]-2-pyridyl}acetate (205676-85-3) → ethyl 2-[6-(methylamino)-2-pyridyl]acetate (205676-86-4)

Guidance literature:

With trifluoroacetic acid; In dichloromethane; at 20 ℃; for 16h;

DOI:10.1021/jm049725u

Reference yield:

ethyl 2-{6-[(tert-butoxy)-N-methylcarbonylamino]-pyridin-2-yl}acetate → ethyl 2-[6-(methylamino)-2-pyridyl]acetate (205676-86-4)

Guidance literature:

With trifluoroacetic acid; In dichloromethane;

Reference yield:

2-Amino-6-methylpyridine (1824-81-3) → ethyl 2-[6-(methylamino)-2-pyridyl]acetate (205676-86-4)

Guidance literature:

Multi-step reaction with 4 steps

1.1: 16 h / 60 °C

2.1: NaH / dimethylformamide / 1.25 h / 0 - 20 °C

2.2: 7.56 g / dimethylformamide / 16 h / 20 °C

3.1: lithium diisopropylamide / tetrahydrofuran / 0.25 h / -78 °C

3.2: 60 percent / tetrahydrofuran / 2.25 h / -78 - 0 °C

4.1: 100 percent / CF₃CO₂H / CH₂Cl₂ / 16 h / 20 °C

With sodium hydride; trifluoroacetic acid; lithium diisopropyl amide; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide;

DOI:10.1021/jm049725u

upstream raw materials:

ethyl 2-{6-[(tert-butoxy)-N-methylcarbonylamino]-2-pyridyl}acetate

2-Amino-6-methylpyridine

2-(tert-butoxycarbonylamino)-6-picoline

(tert-butoxy)-N-methyl-N-[6-methyl-(2-pyridyl)]carboxamide

Downstream raw materials:

ethyl 5-(3-{2-[6-(methylamino)(2-pyridyl)]ethoxy}phenoxy)-4-oxopentanoate

[6-(2-{3-[1,1-bis(methylethyl)-2-methyl-1-silapropoxy]phenoxy}ethyl)(2-pyridyl)]methylamine

2-methylamino-6-(2-hydroxyethyl)pyridine