2-Chloromethyl-3,4-dimethoxypyridine-N-oxide

Base Information

• Chemical Name: 2-Chloromethyl-3,4-dimethoxypyridine-N-oxide
• CAS No.: 953787-47-8
• Molecular Formula: C8H10ClNO3
• Molecular Weight: 203.6229
• Mol file: 953787-47-8.mol

Synonyms:Reaxys ID: 11166863;Pantoprazole Impurity 50;Pantoprazole Impurity 35;Pantoprazole Sodium Impurity W;2-Chloromethyl-3,4-dimethoxypyridine-N-oxide;2-(ChloroMethyl)-3,4-diMethoxy-pyridine 1-Oxide;Pyridine, 2-(chloromethyl)-3,4-dimethoxy-, 1-oxide;2-(Chloromethyl)-3,4-dimethoxypyridine 1-oxide (Pantoprazole Impurity)

Chemical Property of 2-Chloromethyl-3,4-dimethoxypyridine-N-oxide

Chemical Property:

• Vapor Pressure: 1.17E-05mmHg at 25°C
• Boiling Point: 380.7°C at 760 mmHg
• PKA: 1.84±0.10(Predicted)
• Flash Point: 184.1°C
• Density: 1.26g/cm³
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• Solubility.: Acetonitrile, Chloroform, Dichloromethane, Ethyl Acetate, Methanol

Purity/Quality:

97% ^*data from raw suppliers

2-Chloromethyl-3,4-dimethoxypyridine-N-oxide ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 2-Chloromethyl-3,4-dimethoxypyridine-N-oxide (cas# 953787-47-8) is a compound useful in organic synthesis.

Technology Process of 2-Chloromethyl-3,4-dimethoxypyridine-N-oxide

There total 1 articles about 2-Chloromethyl-3,4-dimethoxypyridine-N-oxide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

2-Chloromethyl-3,4-dimethoxy-pyridine; hydrochloride (72830-09-2) → 2-chloromethyl-3,4-dimethoxypyridine-N-oxide (953787-47-8)

Guidance literature:

2-Chloromethyl-3,4-dimethoxy-pyridine; hydrochloride; With sodium hydrogencarbonate; In chloroform;

With 3-chloro-benzenecarboperoxoic acid; at 5 ℃; for 2.41667h; Further stages.;

DOI:10.1080/00397910701470693

Reference yield: 98.44%

2-chloromethyl-3,4-dimethoxypyridine-N-oxide (953787-47-8) + 5-(difluoromethoxy)-2-mercapto-1H-benzimidazole (97963-62-7) → 5-(difluoromethoxy)-2-[[(3,4-dimethoxypyridin-2-yl-1-oxide)methyl]sulfanyl]-1H-benzoimidazole (953787-51-4)

Guidance literature:

With potassium carbonate; In N,N-dimethyl-formamide; at 20 ℃;

DOI:10.1080/00397910701470693

Reference yield:

2-chloromethyl-3,4-dimethoxypyridine-N-oxide (953787-47-8) → 5-(difluoromethoxy)-2-[(3,4-dimethoxypyridin-2-yl-1-oxide)methylsulfonyl]-1H-benzoimidazole (953787-55-8)

Guidance literature:

Multi-step reaction with 2 steps

1: 98.44 percent / potassium carbonate / dimethylformamide / 20 °C

2: m-chloroperbenzoic acid / CH₂Cl₂ / 2.67 h / 0 °C

With potassium carbonate; 3-chloro-benzenecarboperoxoic acid; In dichloromethane; N,N-dimethyl-formamide;

DOI:10.1080/00397910701470693

upstream raw materials:

2-Chloromethyl-3,4-dimethoxy-pyridine; hydrochloride

Downstream raw materials:

5-(difluoromethoxy)-2-[[(3,4-dimethoxypyridin-2-yl-1-oxide)methyl]sulfanyl]-1H-benzoimidazole

5-(difluoromethoxy)-2-[(3,4-dimethoxypyridin-2-yl-1-oxide)methylsulfonyl]-1H-benzoimidazole