Icariin derivative

Base Information

• Chemical Name: Icariin derivative
• CAS No.: 1067198-74-6
• Molecular Formula: C25H28O8
• Molecular Weight: 456.493
• Mol file: 1067198-74-6.mol

Synonyms:Icariin derivative;5-hydroxy-3,7-bis(2-hydroxyethoxy)-2-(4-Methoxyphenyl)-8-(3-Methylbut-2-en-1-yl)-4H-chroMen-4-one

Chemical Property of Icariin derivative

Chemical Property:

• Melting Point: 152 - 153 °C
• Boiling Point: 710.3±60.0 °C(Predicted)
• PKA: 6.09±0.40(Predicted)
• PSA: 118.59000
• Density: 1.34±0.1 g/cm3(Predicted)
• LogP: 3.42510

Purity/Quality:

98%min, ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Icariin derivative

There total 4 articles about Icariin derivative which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 73.0%

icaritin (118525-40-9) + 2-bromoethanol (540-51-2) → 5-hydroxy-3,7-bis(2-hydroxyethoxy)-2-(4-methoxyphenyl)-8-(3-methylbut-2-en-1-yl)-4H-chromen-4-one (1067198-74-6)

Guidance literature:

With potassium carbonate; In acetone; for 6h; Reflux;

DOI:10.1016/j.ejmech.2015.06.006

Reference yield: 20.2%

icariside II (113558-15-9) + 2-bromoethanol (540-51-2) → 5-hydroxy-3,7-bis(2-hydroxyethoxy)-2-(4-methoxyphenyl)-8-(3-methylbut-2-en-1-yl)-4H-chromen-4-one (1067198-74-6)

Guidance literature:

With potassium carbonate; In acetone; for 8h; Reflux;

DOI:10.1021/np800049y

Reference yield:

icariside II (113558-15-9) → 5-hydroxy-3,7-bis(2-hydroxyethoxy)-2-(4-methoxyphenyl)-8-(3-methylbut-2-en-1-yl)-4H-chromen-4-one (1067198-74-6)

Guidance literature:

Multi-step reaction with 2 steps

1: sulfuric acid / ethanol; water / 5 h / 50 °C

2: potassium carbonate / acetone / Reflux; Inert atmosphere

With sulfuric acid; potassium carbonate; In ethanol; water; acetone;

upstream raw materials:

icariside II

2-bromoethanol

icaritin

Refernces

• 1、 Wang, Chen,Wu, Ping,Shi, Jing-Fang,Jiang, Zi-Hua,Wei, Xiao-Yi. "Synthesis and cancer cell growth inhibitory activity of icaritin derivatives". . p. 139 - 150. Retrieved 2015.
• 2、 -. "Icaritin (ICT) derivative and preparation method and application thereof". Paragraph 0038-0041. . Retrieved 2019/11/04.