1-Piperidinecarboxylic acid, 4-amino-3-methoxy-, 1,1-dimethylethyl ester, (3S,4R)-

Base Information

• Chemical Name: 1-Piperidinecarboxylic acid, 4-amino-3-methoxy-, 1,1-dimethylethyl ester, (3S,4R)-
• CAS No.: 1171125-92-0
• Molecular Formula: C11H22N2O3
• Molecular Weight: 230.304
• Mol file: 1171125-92-0.mol

Synonyms:(3S,4R)-4-AMino-3-Methoxy...;tert-butyl (3S,4R)-4-amino-3-methoxypiperidine-1-carboxylate;2-Methyl-2-propanyl (3S,4R)-4-amino-3-methoxy-1-piperidineca...;1-Piperidinecarboxylic acid, 4-amino-3-methoxy-, 1,1-dimethylethyl ester, (3S,4R)-

Chemical Property of 1-Piperidinecarboxylic acid, 4-amino-3-methoxy-, 1,1-dimethylethyl ester, (3S,4R)-

Chemical Property:

• Boiling Point: 306.2±42.0 °C(Predicted)
• PKA: 9.42±0.40(Predicted)
• PSA: 64.79000
• Density: 1.07±0.1 g/cm3(Predicted)
• LogP: 1.60770
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C

Purity/Quality:

97% ^*data from raw suppliers

(3S,4R)-4-Amino-3-methoxypiperidine-1-carboxylic acid, tert-butyl ester ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1-Piperidinecarboxylic acid, 4-amino-3-methoxy-, 1,1-dimethylethyl ester, (3S,4R)-

There total 4 articles about 1-Piperidinecarboxylic acid, 4-amino-3-methoxy-, 1,1-dimethylethyl ester, (3S,4R)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

tert-butyl (3S,4R)-4-{[(benzyloxy)carbonyl]amino}-3-methoxypi peridine-1-carboxylate → tert-butyl (3S,4R)-4-amino-3-methoxypiperidine-1-carboxylate (1171125-92-0,1171124-68-7,1232059-97-0)

Guidance literature:

With palladium 10% on activated carbon; In methanol; at 20 ℃; for 1.3h; Inert atmosphere;

Reference yield:

tert-butyl cis(±)-4-amino-3-methoxypiperidine-1-carboxylate (1171124-68-7,1232059-97-0) → tert-butyl (3S,4R)-4-amino-3-methoxypiperidine-1-carboxylate (1171125-92-0,1171124-68-7,1232059-97-0)

Guidance literature:

Multi-step reaction with 3 steps

1: N-ethyl-N,N-diisopropylamine / dichloromethane / 1 h / Cooling with ice

2: CHIRALCEL OJ-H / hexane; isopropyl alcohol

3: palladium 10% on activated carbon / methanol / 1.3 h / 20 °C / Inert atmosphere

With palladium 10% on activated carbon; N-ethyl-N,N-diisopropylamine; In methanol; hexane; dichloromethane; isopropyl alcohol;

Reference yield:

tert-butyl cis(±)-4-{[(benzyloxy)carbonyl]amino}-3-methoxypiperidine-1-carboxylate → tert-butyl (3S,4R)-4-amino-3-methoxypiperidine-1-carboxylate (1171125-92-0,1171124-68-7,1232059-97-0)

Guidance literature:

Multi-step reaction with 2 steps

1: CHIRALCEL OJ-H / hexane; isopropyl alcohol

2: palladium 10% on activated carbon / methanol / 1.3 h / 20 °C / Inert atmosphere

With palladium 10% on activated carbon; In methanol; hexane; isopropyl alcohol;

upstream raw materials:

tert-butyl cis(±)-4-amino-3-methoxypiperidine-1-carboxylate

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