2,2-DIMETHYL-PROPIONIC ACID 6-METHOXY-1-OXO-1,3-DIHYDRO-ISOINDOL-2-YLMETHYL ESTER

Base Information

• Chemical Name: 2,2-DIMETHYL-PROPIONIC ACID 6-METHOXY-1-OXO-1,3-DIHYDRO-ISOINDOL-2-YLMETHYL ESTER
• CAS No.: 944718-09-6
• Molecular Formula: C15H19NO4
• Molecular Weight: 277.32
• Hs Code.: 2915900090
• Mol file: 944718-09-6.mol

Synonyms:2,2-DIMETHYL-PROPIONIC ACID 6-METHOXY-1-OXO-1,3-DIHYDRO-ISOINDOL-2-YLMETHYL ESTER;(6-Methoxy-1-oxoisoindolin-2-yl)Methyl pivalate

Chemical Property of 2,2-DIMETHYL-PROPIONIC ACID 6-METHOXY-1-OXO-1,3-DIHYDRO-ISOINDOL-2-YLMETHYL ESTER

Chemical Property:

• PSA: 55.84000
• LogP: 2.13570
• Storage Temp.: 2-8°C

Purity/Quality:

97% ^*data from raw suppliers

(6-Methoxy-1-oxoisoindolin-2-yl)methylpivalate 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2,2-DIMETHYL-PROPIONIC ACID 6-METHOXY-1-OXO-1,3-DIHYDRO-ISOINDOL-2-YLMETHYL ESTER

There total 5 articles about 2,2-DIMETHYL-PROPIONIC ACID 6-METHOXY-1-OXO-1,3-DIHYDRO-ISOINDOL-2-YLMETHYL ESTER which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

Chloromethyl pivalate (18997-19-8) + 6-methoxy-2,3-dihydro-isoindol-1-one (22246-66-8,132680-54-7) → 2,2-Dimethyl-propionic acid 6-methoxy-1-oxo-1,3-dihydro-isoindol-2-ylmethyl ester (944718-09-6)

Guidance literature:

With 1,3-dimethyl-3,4,5,6-tetrahydro-2(1H)-pyrimidinone; potassium tert-butylate; In tetrahydrofuran;

DOI:10.1016/j.bmcl.2010.10.081

Reference yield: 67.0%

Chloromethyl pivalate (18997-19-8) → 2,2-Dimethyl-propionic acid 6-methoxy-1-oxo-1,3-dihydro-isoindol-2-ylmethyl ester (944718-09-6)

Guidance literature:

6-methoxy-2,3-dihydro-isoindol-1-one; With 1,3-dimethyl-3,4,5,6-tetrahydro-2(1H)-pyrimidinone; sodium t-butanolate; In tetrahydrofuran; for 5h;

Chloromethyl pivalate; In tetrahydrofuran;

Reference yield:

methyl 5-methoxy-2-methyl-benzoate (73502-03-1) → 2,2-Dimethyl-propionic acid 6-methoxy-1-oxo-1,3-dihydro-isoindol-2-ylmethyl ester (944718-09-6)

Guidance literature:

Multi-step reaction with 3 steps

1: N-Bromosuccinimide; dibenzoyl peroxide / tetrachloromethane / 3 h / Reflux

2: ammonia / methanol / 60 °C / Sealed tube

3: sodium t-butanolate; 1,3-dimethyl-3,4,5,6-tetrahydro-2(1H)-pyrimidinone / tetrahydrofuran / 5 h

With 1,3-dimethyl-3,4,5,6-tetrahydro-2(1H)-pyrimidinone; N-Bromosuccinimide; ammonia; sodium t-butanolate; dibenzoyl peroxide; In tetrahydrofuran; methanol; tetrachloromethane;

upstream raw materials:

Chloromethyl pivalate

6-methoxy-2,3-dihydro-isoindol-1-one

methyl 5-methoxy-2-methyl-benzoate

methyl 2-(bromomethyl)-5-methoxy-benzoate

Downstream raw materials:

2-Bromomethyl-6-methoxy-2,3-dihydro-isoindol-1-one

(R)-2-Methoxycarbonylamino-2-(6-methoxy-1-oxo-1,3-dihydro-isoindol-2-ylmethyl)-4-(4-sulfo-phenyl)-but-3-ynoic acid methyl ester