ethyl 3-cyclopropyl-2,2-difluoropropanoate

Base Information

Chemical Name:ethyl 3-cyclopropyl-2,2-difluoropropanoate
CAS No.:1267593-90-7
Molecular Formula:C8H12F2O2
Molecular Weight:178.18
Hs Code.:
Mol file:1267593-90-7.mol

Synonyms:GKQCAZRAOOHGOF-UHFFFAOYSA-N;Ethyl 3-cyclopropyl-2,2-difluoropropanoate;Cyclopropanepropanoic acid, α,α-difluoro-, ethyl ester

Suppliers and Price of ethyl 3-cyclopropyl-2,2-difluoropropanoate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
ethyl3-cyclopropyl-2,2-difluoropropanoate
25mg
$ 265.00

AK Scientific
Ethyl3-cyclopropyl-2,2-difluoropropanoate
100mg
$ 580.00

Total 9 raw suppliers

Chemical Property of ethyl 3-cyclopropyl-2,2-difluoropropanoate

Chemical Property:

Boiling Point:178.7±25.0 °C(Predicted)
PSA：26.30000
Density:1.151±0.06 g/cm3(Predicted)
LogP:1.98490

Purity/Quality:

97% ^*data from raw suppliers

ethyl3-cyclopropyl-2,2-difluoropropanoate ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of ethyl 3-cyclopropyl-2,2-difluoropropanoate

There total 3 articles about ethyl 3-cyclopropyl-2,2-difluoropropanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 75-11-6
diiodomethane

: 110482-96-7
2,2-difluoro-4-pentenoic acid ethyl ester

: 1267593-90-7
ethyl 3-cyclopropyl-2,2-difluoropropanoate

Guidance literature:: diiodomethane; With diethylzinc; trifluoroacetic acid; In hexane; dichloromethane; at -5 - 0 ℃; for 0.833333h;

2,2-difluoro-4-pentenoic acid ethyl ester; In hexane; dichloromethane; for 16.42h; Product distribution / selectivity; Cooling; Reflux;

Reference yield: 82.6%

: 64025-67-8
ethyl 3-cyclopropyl-2-oxopropanoate

: 1267593-90-7
ethyl 3-cyclopropyl-2,2-difluoropropanoate

Guidance literature:: ethyl 3-cyclopropyl-2-oxopropanoate; With (bis-(2-methoxyethyl)amino)sulfur trufluoride; In dichloromethane; at -5 ℃; for 0.333333h; Inert atmosphere;

ethanol; In dichloromethane; at 20 ℃; for 15h;

Reference yield:

: 527385-30-4
ethyl 2-(cyclopropylmethyl)-1,3-dithiane-2-carboxylate

: 1267593-90-7
ethyl 3-cyclopropyl-2,2-difluoropropanoate

Guidance literature:: Multi-step reaction with 2 steps

1.1: N-Bromosuccinimide / water; acetone / 1.5 h / -5 °C

2.1: (bis-(2-methoxyethyl)amino)sulfur trufluoride / dichloromethane / 0.33 h / -5 °C / Inert atmosphere

2.2: 15 h / 20 °C

With N-Bromosuccinimide; (bis-(2-methoxyethyl)amino)sulfur trufluoride; In dichloromethane; water; acetone;