Methyl3-oxo-3,4-dihydro-2H-pyrido[3,2-b][1,4]thiazine-6-carboxylate

Base Information

• Chemical Name: Methyl3-oxo-3,4-dihydro-2H-pyrido[3,2-b][1,4]thiazine-6-carboxylate
• CAS No.: 443956-13-6
• Molecular Formula: C9H8N2O3S
• Molecular Weight: 224.23600
• Hs Code.: 2934999090
• Mol file: 443956-13-6.mol

Synonyms:Methyl3-oxo-3,4-dihydro-2H-pyrido[3,2-b][1,4]thiazine-6-carboxylate

Chemical Property of Methyl3-oxo-3,4-dihydro-2H-pyrido[3,2-b][1,4]thiazine-6-carboxylate

Chemical Property:

• PSA: 97.08000
• LogP: 0.99750
• Storage Temp.: 2-8°C

Purity/Quality:

98%Min ^*data from raw suppliers

Methyl3-oxo-3,4-dihydro-2H-pyrido[3,2-b][1,4]thiazine-6-carboxylate 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Methyl3-oxo-3,4-dihydro-2H-pyrido[3,2-b][1,4]thiazine-6-carboxylate

There total 3 articles about Methyl3-oxo-3,4-dihydro-2H-pyrido[3,2-b][1,4]thiazine-6-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

6-amino-5-bromo-pyridine-2-carboxylic acid methyl ester (178876-82-9) → methyl 3-oxo-3,4-dihydro-2H-pyrido[3,2-b][1,4]thiazine-6-carboxylate (443956-13-6)

Guidance literature:

ethyl 2-sulfanylacetate; With sodium hydride; In N,N-dimethyl-formamide; at 0 ℃; for 1h;

6-amino-5-bromo-pyridine-2-carboxylic acid methyl ester; In N,N-dimethyl-formamide; at 20 ℃; for 16h;

Reference yield: 100.0%

ethyl 2-sulfanylacetate (623-51-8) + 6-amino-5-bromo-pyridine-2-carboxylic acid methyl ester (178876-82-9) → methyl 3-oxo-3,4-dihydro-2H-pyrido[3,2-b][1,4]thiazine-6-carboxylate (443956-13-6)

Guidance literature:

ethyl 2-sulfanylacetate; With sodium hydride; In N,N-dimethyl-formamide; at 0 ℃; for 1h;

6-amino-5-bromo-pyridine-2-carboxylic acid methyl ester; In N,N-dimethyl-formamide; at 20 ℃;

DOI:10.1016/j.tetlet.2010.07.095

Reference yield:

Methyl thioglycolate (2365-48-2) + 6-amino-5-bromo-pyridine-2-carboxylic acid methyl ester (178876-82-9) → methyl 3-oxo-3,4-dihydro-2H-pyrido[3,2-b][1,4]thiazine-6-carboxylate (443956-13-6)

Guidance literature:

Methyl thioglycolate; With sodium hydride; In N,N-dimethyl-formamide; for 1h;

6-amino-5-bromo-pyridine-2-carboxylic acid methyl ester; In N,N-dimethyl-formamide; at 20 ℃; for 12h;

upstream raw materials:

6-amino-5-bromo-pyridine-2-carboxylic acid methyl ester

ethyl 2-sulfanylacetate

Methyl thioglycolate

Downstream raw materials:

3-oxo-3,4-dihydro-2H-pyrido[3,2-b][1,4]thiazine-6-carboxylic acid

3-oxo-3,4-dihydro-2H-pyrido[3,2-b][1,4]thiazine-6-carbaldehyde