Technology Process of 8-Bromo-3,7-difluoro-2-methoxy-1,5-naphthyridine
There total 7 articles about 8-Bromo-3,7-difluoro-2-methoxy-1,5-naphthyridine which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
8-hydroxy-3,7-difluoro-2-(methyloxy)-1,5-naphthyridine;
With
phosphorus tribromide;
In
N,N-dimethyl-formamide;
for 1.5h;
With
potassium carbonate;
In
water; N,N-dimethyl-formamide;
Alkaline conditions;
- Guidance literature:
-
Multi-step reaction with 7 steps
1.1: methanol / 4 h / Heating / reflux
1.2: pH 2 / Acidic conditions
2.1: diphenyl phosphoryl azide; triethylamine / toluene / 2 h / 100 °C
3.1: cesium fluoride / bis(tri-t-butylphosphine)palladium(0) / dioxane,1,4 / 100 °C
4.1: sodium hydrogencarbonate; Selectfluor / water; acetonitrile / 0.58 h / 0 - 20 °C
4.2: 0.17 h
5.1: toluene / 2 h / 40 °C
6.1: trifluoroacetic acid / dichloromethane / 0.5 h / 20 °C
6.2: Alkaline conditions
7.1: phosphorus tribromide / N,N-dimethyl-formamide / 1.5 h
7.2: Alkaline conditions
With
diphenyl phosphoryl azide; phosphorus tribromide; sodium hydrogencarbonate; Selectfluor; triethylamine; cesium fluoride; trifluoroacetic acid;
bis(tri-t-butylphosphine)palladium(0);
In
methanol; dioxane,1,4; dichloromethane; water; N,N-dimethyl-formamide; toluene; acetonitrile;
- Guidance literature:
-
Multi-step reaction with 6 steps
1.1: diphenyl phosphoryl azide; triethylamine / toluene / 2 h / 100 °C
2.1: cesium fluoride / bis(tri-t-butylphosphine)palladium(0) / dioxane,1,4 / 100 °C
3.1: sodium hydrogencarbonate; Selectfluor / water; acetonitrile / 0.58 h / 0 - 20 °C
3.2: 0.17 h
4.1: toluene / 2 h / 40 °C
5.1: trifluoroacetic acid / dichloromethane / 0.5 h / 20 °C
5.2: Alkaline conditions
6.1: phosphorus tribromide / N,N-dimethyl-formamide / 1.5 h
6.2: Alkaline conditions
With
diphenyl phosphoryl azide; phosphorus tribromide; sodium hydrogencarbonate; Selectfluor; triethylamine; cesium fluoride; trifluoroacetic acid;
bis(tri-t-butylphosphine)palladium(0);
In
dioxane,1,4; dichloromethane; water; N,N-dimethyl-formamide; toluene; acetonitrile;
