Ethyl2-(3-fluoro-6-Methoxy-1,5-naphthyridin-4-yl)acetate

Base Information

• Chemical Name: Ethyl2-(3-fluoro-6-Methoxy-1,5-naphthyridin-4-yl)acetate
• CAS No.: 1207621-43-9
• Molecular Formula: C13H13FN2O3
• Molecular Weight: 264.25
• Hs Code.: 2933990090
• Mol file: 1207621-43-9.mol

Synonyms:Ethyl2-(3-fluoro-6-Methoxy-1,5-naphthyridin-4-yl)acetate

Chemical Property of Ethyl2-(3-fluoro-6-Methoxy-1,5-naphthyridin-4-yl)acetate

Chemical Property:

• PSA: 61.31000
• LogP: 1.88310
• Storage Temp.: 2-8°C

Purity/Quality:

99% ^*data from raw suppliers

Ethyl 2-(3-fluoro-6-methoxy-1,5-naphthyridin-4-yl)acetate 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Ethyl2-(3-fluoro-6-Methoxy-1,5-naphthyridin-4-yl)acetate

There total 2 articles about Ethyl2-(3-fluoro-6-Methoxy-1,5-naphthyridin-4-yl)acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

2-(3-fluoro-6-methoxy-[1,5]naphthyridin-4-yl)-malonic acid diethyl ester (1220978-38-0) → (3-fluoro-6-methoxy-[1,5]naphthyridin-4-yl)-acetic acid ethyl ester (1207621-43-9)

Guidance literature:

With water; lithium chloride; In dimethyl sulfoxide; at 110 ℃; for 32h;

Reference yield:

8-bromo-7-fluoro-2-methoxy-1,5-naphthyridine (724788-70-9) → (3-fluoro-6-methoxy-[1,5]naphthyridin-4-yl)-acetic acid ethyl ester (1207621-43-9)

Guidance literature:

Multi-step reaction with 2 steps

1.1: sodium hydride / 1,4-dioxane; mineral oil / 1.08 h / 20 - 80 °C

1.2: 20 - 100 °C

2.1: water; lithium chloride / dimethyl sulfoxide / 32 h / 110 °C

With water; sodium hydride; lithium chloride; In 1,4-dioxane; dimethyl sulfoxide; mineral oil;

upstream raw materials:

2-(3-fluoro-6-methoxy-[1,5]naphthyridin-4-yl)-malonic acid diethyl ester

8-bromo-7-fluoro-2-methoxy-1,5-naphthyridine

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