8-BROMO-7-FLUORO-2-METHOXY-1,5-NAPHTHYRIDINE

Base Information

• Chemical Name: 8-BROMO-7-FLUORO-2-METHOXY-1,5-NAPHTHYRIDINE
• CAS No.: 724788-70-9
• Molecular Formula: C9H6 Br F N2 O
• Molecular Weight: 257.062
• Mol file: 724788-70-9.mol

Synonyms:4-Bromo-3-fluoro-6-methoxy-[1,5]naphthyridine;8-Bromo-7-fluoro-2-(methoxy)-1,5-naphthyridine; 8-Bromo-7-fluoro-2-(methyloxy)-1,5-naphthyridine

Chemical Property of 8-BROMO-7-FLUORO-2-METHOXY-1,5-NAPHTHYRIDINE

Chemical Property:

• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.626
• Boiling Point: 324.699°C at 760 mmHg
• Flash Point: 150.173°C
• PSA: 35.01000
• Density: 1.665g/cm³
• LogP: 2.54000
• Storage Temp.: 2-8°C

Purity/Quality:

97% ^*data from raw suppliers

8-Bromo-7-fluoro-2-methoxy-1,5-naphthyridine 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 8-BROMO-7-FLUORO-2-METHOXY-1,5-NAPHTHYRIDINE

There total 21 articles about 8-BROMO-7-FLUORO-2-METHOXY-1,5-NAPHTHYRIDINE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

3-fluoro-6-methoxy-1,5-naphthyridin-4-ol (1075259-77-6) → 8-bromo-7-fluoro-2-methoxy-1,5-naphthyridine (724788-70-9)

Guidance literature:

With phosphorus tribromide; In N,N-dimethyl-formamide; at 50 - 70 ℃; for 1h;

DOI:10.1021/op500100b

Reference yield: 59.0%

C9H6BrN4O(1+) (724788-68-5) → 8-bromo-7-fluoro-2-methoxy-1,5-naphthyridine (724788-70-9)

Guidance literature:

C₉H₆BrN₄O⁽¹⁺⁾; With nitrosyl tetrafluoroborate; In tetrahydrofuran; at -10 ℃; for 1.5h;

In decalin; at 100 ℃; for 1h;

DOI:10.1021/ml500069w

Reference yield: 40.0%

4-bromo-6-methoxy-[1,5]naphthyridine-3-diazonium tetrafluoroborate → 8-bromo-7-fluoro-2-methoxy-1,5-naphthyridine (724788-70-9)

Guidance literature:

In decalin; at 180 ℃; for 0.0833333h;

upstream raw materials:

6-methoxy-pyridin-3-ylamine

ethyl 4-bromo-6-methoxy-1,5-naphthyridine-3-carboxylate

4-bromo-6-methoxy-1,5-naphthyridine-3-carboxylic acid

4-bromo-6-(methyloxy)-1,5-naphthyridin-3-amine

Downstream raw materials:

8-allyl-7-fluoro-2-methoxy-1,5-naphthyridine

7-fluoro-2-methoxy-1,5-naphthyridine

(E)-7-fluoro-2-methoxy-8-styryl-1,5-naphthyridine

[1-(3-fluoro-6-methoxy-[1,5]naphthyridin-4-yl)-piperidin-4-yl]-carbamic acid benzyl ester