2-AMINO-6-BROMOPYRIDIN-3-OL

Base Information

• Chemical Name: 2-AMINO-6-BROMOPYRIDIN-3-OL
• CAS No.: 934758-27-7
• Molecular Formula: C5H5BrN2O
• Molecular Weight: 189.01
• Hs Code.: 2933399090
• Mol file: 934758-27-7.mol

Synonyms:2-AMINO-6-BROMOPYRIDIN-3-OL;2-Amino-6-bromo-3-hydroxypyridine;2-Amino-6-bromo-3-pyridinol

Chemical Property of 2-AMINO-6-BROMOPYRIDIN-3-OL

Chemical Property:

• Boiling Point: 421.3±45.0 °C(Predicted)
• PKA: 4.59±0.23(Predicted)
• PSA: 59.14000
• Density: 1.898
• LogP: 1.71310
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C

Purity/Quality:

97% ^*data from raw suppliers

2-amino-6-bromopyridin-3-ol ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-AMINO-6-BROMOPYRIDIN-3-OL

There total 2 articles about 2-AMINO-6-BROMOPYRIDIN-3-OL which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.55%

6-bromo-2-nitropyridin-3-ol (443956-08-9) → 2-amino-6-bromo-3-hydroxypyridine (934758-27-7)

Guidance literature:

With iron; ammonium chloride; In ethanol; water; at 75 ℃; for 2h;

Reference yield:

3-hydroxy-2-nitropyridine (15128-82-2) → 2-amino-6-bromo-3-hydroxypyridine (934758-27-7)

Guidance literature:

Multi-step reaction with 2 steps

1.1: sodium methylate / methanol / 0.5 h / 20 °C / Inert atmosphere

1.2: 4 h / 0 - 5 °C / Inert atmosphere

2.1: zinc; ammonium chloride / ethanol / 16 h / 50 °C / Inert atmosphere

With sodium methylate; ammonium chloride; zinc; In methanol; ethanol;

Reference yield: 70.0%

2-amino-6-bromo-3-hydroxypyridine (934758-27-7) + bis(trichloromethyl) carbonate (32315-10-9) → 5-bromooxazolo[4,5-b]pyridin-2(3H)-one (1092569-10-2)

Guidance literature:

With triethylamine; In dichloromethane; at 20 ℃; for 2h;

upstream raw materials:

6-bromo-2-nitropyridin-3-ol

3-hydroxy-2-nitropyridine

Downstream raw materials:

6-bromo-2-methyl-oxazolo[4,5-b]pyridine

5-bromo-2-(4-fluorobenzyl)oxazolo[4,5-b]pyridine

5-(2-(4-fluorobenzyl)oxazolo[4,5-b]pyridin-5-yl)-2-(4-fluorophenyl)-N-methyl-6-(N-methylmethylsulfonamido)benzofuran-3-carboxamide

6-bromo-2,2-dimethyl-2H,3H,4H-pyrido[3,2-b][1,4]oxazin-3-one