(2S,4S)-4-(2-Propen-1-yl)-1,2-pyrrolidinedicarboxylic acid 1-tert-butyl ester

Base Information

Chemical Name:(2S,4S)-4-(2-Propen-1-yl)-1,2-pyrrolidinedicarboxylic acid 1-tert-butyl ester
CAS No.:934470-80-1
Molecular Formula:C₁₃H₂₁NO₄
Molecular Weight:255.314
Hs Code.:
Mol file:934470-80-1.mol

Synonyms:(2S,4S)-4-Allyl-1-(tert-butoxycarbonyl)pyrrolidine-2-carboxylic acid;(2S,4S)-4-(2-Propen-1-yl)-1,2-pyrrolidinedicarboxylic acid 1-tert-butyl ester

Suppliers and Price of (2S,4S)-4-(2-Propen-1-yl)-1,2-pyrrolidinedicarboxylic acid 1-tert-butyl ester

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Chemenu
(2S,4S)-4-allyl-1-(tert-butoxycarbonyl)pyrrolidine-2-carboxylicacid 95%
1g
$ 505.00

American Custom Chemicals Corporation
(2S,4S)-4-ALLYL-1-(TERT-BUTOXYCARBONYL)PYRROLIDINE-2-CARBOXYLIC ACID 95.00%
5MG
$ 495.03

Alichem
(2S,4S)-4-Allyl-1-(tert-butoxycarbonyl)pyrrolidine-2-carboxylicacid
1g
$ 453.44

Total 8 raw suppliers

Chemical Property of (2S,4S)-4-(2-Propen-1-yl)-1,2-pyrrolidinedicarboxylic acid 1-tert-butyl ester

Chemical Property:

Boiling Point:369 oC
Flash Point:177 oC
PSA：66.84000
Density:1.117
LogP:2.21060
Storage Temp.:2-8°C

Purity/Quality:

98% ^*data from raw suppliers

(2S,4S)-4-allyl-1-(tert-butoxycarbonyl)pyrrolidine-2-carboxylicacid 95% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of (2S,4S)-4-(2-Propen-1-yl)-1,2-pyrrolidinedicarboxylic acid 1-tert-butyl ester

There total 9 articles about (2S,4S)-4-(2-Propen-1-yl)-1,2-pyrrolidinedicarboxylic acid 1-tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

: 663956-65-8
1-tert-butyl 2-methyl (2S,4S)-4-allyl-1,2-pyrrolidinedicarboxylate

: 934470-80-1
(2S,4S)-4-allyl-1-(tert-butoxycarbonyl)-2-pyrrolidinecarboxylic acid

Guidance literature:: In tetrahydrofuran;

Reference yield:

: 213476-05-2
(2S,4S)-4-allyl-5-oxopyrrolidine-1,2-dicarboxylic acid 1-tert-butyl ester 2-methyl ester

: 934470-80-1
(2S,4S)-4-allyl-1-(tert-butoxycarbonyl)-2-pyrrolidinecarboxylic acid

Guidance literature:: Multi-step reaction with 2 steps

1.1: lithium triethylborohydride / tetrahydrofuran / 0.67 h / -78 °C

1.2: H₂O₂ / tetrahydrofuran / 0.33 h / 0 °C

1.3: 89 percent / triethylsilane; BF₃*OEt₂ / CH₂Cl₂ / 3 h / -78 °C

2.1: 86 percent / NaOH / methanol; H₂O / 6 h / 20 °C

With sodium hydroxide; lithium triethylborohydride; In tetrahydrofuran; methanol; water;
DOI:10.1016/j.bmc.2007.01.033

Reference yield:

: 108963-96-8
(S)-1-tert-butoxycarbonyl-5-methoxycarbonyl-pyrrolidin-2-one

: 934470-80-1
(2S,4S)-4-allyl-1-(tert-butoxycarbonyl)-2-pyrrolidinecarboxylic acid

Guidance literature:: Multi-step reaction with 3 steps

1: lithium hexamethyldisilazane; acetic acid / tetrahydrofuran; toluene; ethyl acetate; hexane

2: dihydrogen peroxide; triethylsilane; boron trifluoride diethyl etherate / tetrahydrofuran; ethyl acetate; hexane; water

3: tetrahydrofuran

With triethylsilane; boron trifluoride diethyl etherate; dihydrogen peroxide; acetic acid; lithium hexamethyldisilazane; In tetrahydrofuran; hexane; water; ethyl acetate; toluene;