tert-butyl ((2S)-1-(((2S)-1-((2S,4S)-4-allyl-2-(((2S)-1-(((2S)-1-(cyclopropanesulfonamido)-1-oxo-3-(4-(prop-2-yn-1-yloxy)phenyl)propan-2-yl)amino)-3-(naphthalen-2-yl)-1-oxopropan-2-yl)carbamoyl)pyrrolidin-1-yl)-3,3-dimethyl-1-oxobutan-2-yl)amino)-1-oxopropan-2-yl)(methyl)carbamate

Base Information

Chemical Name:tert-butyl ((2S)-1-(((2S)-1-((2S,4S)-4-allyl-2-(((2S)-1-(((2S)-1-(cyclopropanesulfonamido)-1-oxo-3-(4-(prop-2-yn-1-yloxy)phenyl)propan-2-yl)amino)-3-(naphthalen-2-yl)-1-oxopropan-2-yl)carbamoyl)pyrrolidin-1-yl)-3,3-dimethyl-1-oxobutan-2-yl)amino)-1-oxopropan-2-yl)(methyl)carbamate
CAS No.:1609554-61-1
Molecular Formula:C₅₁H₆₆N₆O₁₀S
Molecular Weight:955.185
Hs Code.:

tert-butyl ((2S)-1-(((2S)-1-((2S,4S)-4-allyl-2-(((2S)-1-(((2S)-1-(cyclopropanesulfonamido)-1-oxo-3-(4-(prop-2-yn-1-yloxy)phenyl)propan-2-yl)amino)-3-(naphthalen-2-yl)-1-oxopropan-2-yl)carbamoyl)pyrrolidin-1-yl)-3,3-dimethyl-1-oxobutan-2-yl)amino)-1-oxopropan-2-yl)(methyl)carbamate

Synonyms:tert-butyl ((2S)-1-(((2S)-1-((2S,4S)-4-allyl-2-(((2S)-1-(((2S)-1-(cyclopropanesulfonamido)-1-oxo-3-(4-(prop-2-yn-1-yloxy)phenyl)propan-2-yl)amino)-3-(naphthalen-2-yl)-1-oxopropan-2-yl)carbamoyl)pyrrolidin-1-yl)-3,3-dimethyl-1-oxobutan-2-yl)amino)-1-oxopropan-2-yl)(methyl)carbamate

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Chemical Property of tert-butyl ((2S)-1-(((2S)-1-((2S,4S)-4-allyl-2-(((2S)-1-(((2S)-1-(cyclopropanesulfonamido)-1-oxo-3-(4-(prop-2-yn-1-yloxy)phenyl)propan-2-yl)amino)-3-(naphthalen-2-yl)-1-oxopropan-2-yl)carbamoyl)pyrrolidin-1-yl)-3,3-dimethyl-1-oxobutan-2-yl)amino)-1-oxopropan-2-yl)(methyl)carbamate

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Technology Process of tert-butyl ((2S)-1-(((2S)-1-((2S,4S)-4-allyl-2-(((2S)-1-(((2S)-1-(cyclopropanesulfonamido)-1-oxo-3-(4-(prop-2-yn-1-yloxy)phenyl)propan-2-yl)amino)-3-(naphthalen-2-yl)-1-oxopropan-2-yl)carbamoyl)pyrrolidin-1-yl)-3,3-dimethyl-1-oxobutan-2-yl)amino)-1-oxopropan-2-yl)(methyl)carbamate

There total 15 articles about tert-butyl ((2S)-1-(((2S)-1-((2S,4S)-4-allyl-2-(((2S)-1-(((2S)-1-(cyclopropanesulfonamido)-1-oxo-3-(4-(prop-2-yn-1-yloxy)phenyl)propan-2-yl)amino)-3-(naphthalen-2-yl)-1-oxopropan-2-yl)carbamoyl)pyrrolidin-1-yl)-3,3-dimethyl-1-oxobutan-2-yl)amino)-1-oxopropan-2-yl)(methyl)carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

: 1609554-60-0
(2S)-2-((2S,4S)-4-allyl-1-((2S)-2-((2S)-2-((tert-butoxycarbonyl)(methyl)amino)propanamido)-3,3-dimethylbutanoyl)pyrrolidine-2-carboxamido)-3-(naphthalen-2-yl)propanoic acid

: 1609554-54-2
(S)-2-amino-N-(cyclopropylsulfonyl)-3-(4-(prop-2-yn-1-yloxy)phenyl)propanamide hydrochloride

: 1609554-61-1
tert-butyl ((2S)-1-(((2S)-1-((2S,4S)-4-allyl-2-(((2S)-1-(((2S)-1-(cyclopropanesulfonamido)-1-oxo-3-(4-(prop-2-yn-1-yloxy)phenyl)propan-2-yl)amino)-3-(naphthalen-2-yl)-1-oxopropan-2-yl)carbamoyl)pyrrolidin-1-yl)-3,3-dimethyl-1-oxobutan-2-yl)amino)-1-oxopropan-2-yl)(methyl)carbamate

Guidance literature:: With 4-methyl-morpholine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; In N,N-dimethyl-formamide; at 20 ℃; for 3h; Inert atmosphere;

Reference yield: 76.0%

: 1434125-73-1
(S)-2-amino-N-(cyclopropylsulfonyl)-3-(4-(prop-2-yn-1-yloxy)phenyl)propanamide

: 1609554-60-0
(2S)-2-((2S,4S)-4-allyl-1-((2S)-2-((2S)-2-((tert-butoxycarbonyl)(methyl)amino)propanamido)-3,3-dimethylbutanoyl)pyrrolidine-2-carboxamido)-3-(naphthalen-2-yl)propanoic acid

: 1609554-61-1
tert-butyl ((2S)-1-(((2S)-1-((2S,4S)-4-allyl-2-(((2S)-1-(((2S)-1-(cyclopropanesulfonamido)-1-oxo-3-(4-(prop-2-yn-1-yloxy)phenyl)propan-2-yl)amino)-3-(naphthalen-2-yl)-1-oxopropan-2-yl)carbamoyl)pyrrolidin-1-yl)-3,3-dimethyl-1-oxobutan-2-yl)amino)-1-oxopropan-2-yl)(methyl)carbamate

Guidance literature:: With 4-methyl-morpholine; hydrogenchloride; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; In N,N-dimethyl-formamide; at 20 ℃; for 3h; Inert atmosphere;
DOI:10.1021/acsmedchemlett.5b00091

Reference yield:

: 108963-96-8
(S)-1-tert-butoxycarbonyl-5-methoxycarbonyl-pyrrolidin-2-one

: 1609554-61-1
tert-butyl ((2S)-1-(((2S)-1-((2S,4S)-4-allyl-2-(((2S)-1-(((2S)-1-(cyclopropanesulfonamido)-1-oxo-3-(4-(prop-2-yn-1-yloxy)phenyl)propan-2-yl)amino)-3-(naphthalen-2-yl)-1-oxopropan-2-yl)carbamoyl)pyrrolidin-1-yl)-3,3-dimethyl-1-oxobutan-2-yl)amino)-1-oxopropan-2-yl)(methyl)carbamate

Guidance literature:: Multi-step reaction with 11 steps

1.1: lithium hexamethyldisilazane / tetrahydrofuran; toluene / 1 h / -78 °C / Inert atmosphere

1.2: 3 h / -78 °C / Inert atmosphere

1.3: 3 h / -78 °C / Inert atmosphere

2.1: lithium triethylborohydride / tetrahydrofuran / 2 h / -78 °C / Inert atmosphere

2.2: 0.5 h / 0 - 20 °C / Inert atmosphere

3.1: boron trifluoride diethyl etherate; triethylsilane / dichloromethane / 2 h / -78 °C / Inert atmosphere

4.1: lithium hydroxide / tetrahydrofuran; water; methanol / 5 h / 20 °C / Inert atmosphere

4.2: 0 °C / pH 3 - 4 / Inert atmosphere

5.1: 4-methyl-morpholine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; 1-hydroxy-7-aza-benzotriazole / N,N-dimethyl-formamide / 0.33 h / 0 °C / Inert atmosphere

5.2: 20 °C / Inert atmosphere

6.1: trifluoroacetic acid / dichloromethane / 3 h / 20 °C / Inert atmosphere

7.1: 4-methyl-morpholine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; 1-hydroxy-7-aza-benzotriazole / N,N-dimethyl-formamide / 0 - 20 °C / Inert atmosphere

8.1: trifluoroacetic acid / dichloromethane / 2 h / 20 °C

9.1: 4-methyl-morpholine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; 1-hydroxy-7-aza-benzotriazole / N,N-dimethyl-formamide / 1.33 h / 0 - 20 °C / Inert atmosphere

10.1: lithium hydroxide; water / tetrahydrofuran; methanol / 5 h / 20 °C / Inert atmosphere

11.1: N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; 4-methyl-morpholine / N,N-dimethyl-formamide / 3 h / 20 °C / Inert atmosphere

With 4-methyl-morpholine; triethylsilane; 1-hydroxy-7-aza-benzotriazole; boron trifluoride diethyl etherate; water; lithium triethylborohydride; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; trifluoroacetic acid; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; lithium hydroxide; lithium hexamethyldisilazane; In tetrahydrofuran; methanol; dichloromethane; water; N,N-dimethyl-formamide; toluene;