Technology Process of (2R,5S)-2,5-Dimethyl-1-phenyl-piperazine
There total 4 articles about (2R,5S)-2,5-Dimethyl-1-phenyl-piperazine which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
2,5-dimethyl-piperazine;
With
[2,2]bipyridinyl; nickel diacetate; sodium hydride;
tert-Amyl alcohol;
In
tetrahydrofuran;
at 65 ℃;
for 2h;
chlorobenzene;
With
styrene;
In
tetrahydrofuran;
at 65 ℃;
for 12h;
DOI:10.1016/S0040-4020(02)00750-0
- Guidance literature:
-
With
hydrogen;
palladium on activated charcoal;
In
ethanol;
for 6h;
Ambient temperature;
- Guidance literature:
-
Multi-step reaction with 2 steps
1: 1.) thionyl chloride, 2.) sodium carbonate / 1.) chloroform, reflux, 2 h, 2.) 210 deg C, 4 h, 250-260 deg C, 1 h
2: 1.2 g / hydrogen / 10percent Pd/C / ethanol / 6 h / Ambient temperature
With
thionyl chloride; hydrogen; sodium carbonate;
palladium on activated charcoal;
In
ethanol;