3-OXO-2,3-DIHYDRO-1H-ISOINDOLE-4-CARBOXYLIC ACID METHYL ESTER

Base Information

• Chemical Name: 3-OXO-2,3-DIHYDRO-1H-ISOINDOLE-4-CARBOXYLIC ACID METHYL ESTER
• CAS No.: 935269-25-3
• Molecular Formula: C₁₀H₉NO₃
• Molecular Weight: 191.186
• Hs Code.: 2933790090
• Mol file: 935269-25-3.mol

Synonyms:3-OXO-2,3-DIHYDRO-1H-ISOINDOLE-4-CARBOXYLIC ACID METHYL ESTER;1H-Isoindole-4-carboxylic acid, 2,3-dihydro-3-oxo-, Methyl ester;Methyl 3-oxo-2,3-dihydro-1H-isoindole-4-carboxylate;Methyl 3-oxoisoindoline-4-carboxylate

Chemical Property of 3-OXO-2,3-DIHYDRO-1H-ISOINDOLE-4-CARBOXYLIC ACID METHYL ESTER

Chemical Property:

• PSA: 58.89000
• LogP: 0.72700

Purity/Quality:

99.3% ^*data from raw suppliers

3-Oxo-2,3-dihydro-1H-isoindole-4-carboxylicAcidMethylEster ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3-OXO-2,3-DIHYDRO-1H-ISOINDOLE-4-CARBOXYLIC ACID METHYL ESTER

There total 1 articles about 3-OXO-2,3-DIHYDRO-1H-ISOINDOLE-4-CARBOXYLIC ACID METHYL ESTER which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 52.0%

3-azidomethyl-phthalic acid dimethyl ester (935269-24-2) → 3-oxo-2,3-dihydro-1H-isoindole-4-carboxylic acid methyl ester (935269-25-3)

Guidance literature:

With water; triphenylphosphine; In tetrahydrofuran; at 25 ℃;

DOI:10.1016/j.bmcl.2008.07.090

Reference yield: 83.0%

3-oxo-2,3-dihydro-1H-isoindole-4-carboxylic acid methyl ester (935269-25-3) → 3-oxo-2,3-dihydro-1H-isoindole-4-carboxylic acid (935269-27-5)

Guidance literature:

With lithium hydroxide; water; In tetrahydrofuran; methanol; at 25 ℃;

DOI:10.1016/j.bmcl.2008.07.090

Reference yield:

3-oxo-2,3-dihydro-1H-isoindole-4-carboxylic acid methyl ester (935269-25-3) → 3-oxoisoindoline-4-carboxamide (935269-26-4)

Guidance literature:

With ammonia; In tetrahydrofuran; water; at 20 ℃; for 0.5h;

upstream raw materials:

3-azidomethyl-phthalic acid dimethyl ester

Downstream raw materials:

3-oxoisoindoline-4-carboxamide

3-oxo-2,3-dihydro-1H-isoindole-4-carboxylic acid

Refernces

• 1、 -. "SUBSTITUTED DIHYDRO-ISOINDOLONES USEFUL IN TREATING KINASE DISORDERS". Page/Page column 68. . Retrieved 2008/06/13.