6-((6-bromo-1H-[1,2,3]triazolo[4,5-b]pyrazin-1-yl)methyl)quinoline

Base Information

• Chemical Name: 6-((6-bromo-1H-[1,2,3]triazolo[4,5-b]pyrazin-1-yl)methyl)quinoline
• CAS No.: 956907-14-5
• Molecular Formula: C14H9BrN6
• Molecular Weight: 341.17
• Mol file: 956907-14-5.mol

Synonyms:6-((6-broMo-1H-[1,2,3]triazolo[4,5-b]pyrazin-1-yl)Methyl)quinoline;Quinoline, 6-[(6-bromo-1H-1,2,3-triazolo[4,5-b]pyrazin-1-yl)methyl]-

Chemical Property of 6-((6-bromo-1H-[1,2,3]triazolo[4,5-b]pyrazin-1-yl)methyl)quinoline

Chemical Property:

• PSA: 69.38000
• LogP: 2.58030

Purity/Quality:

≥95% ^*data from raw suppliers

6-[(6-Bromo-1H-[1,2,3]triazolo[4,5-b]pyrazin-1-yl)methyl]quinoline ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 6-((6-bromo-1H-[1,2,3]triazolo[4,5-b]pyrazin-1-yl)methyl)quinoline

There total 9 articles about 6-((6-bromo-1H-[1,2,3]triazolo[4,5-b]pyrazin-1-yl)methyl)quinoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 73.5%

6-bromo-N2-(quinolin-6-ylmethyl)pyrazine-2,3-diamine (956907-13-4) → 6-((6-bromo-1H-[1,2,3]triazolo[4,5-b]pyrazine-1-yl)methyl)quinoline (956907-14-5)

Guidance literature:

With isopentyl nitrite; In N,N-dimethyl-formamide; at 20 ℃; Cooling with ice;

DOI:10.1016/j.ejmech.2022.114114

Reference yield: 42.0%

6-bromo-N2-(quinolin-6-ylmethyl)pyrazine-2,3-diamine (956907-13-4) + isopentyl nitrite (110-46-3) → 6-((6-bromo-1H-[1,2,3]triazolo[4,5-b]pyrazine-1-yl)methyl)quinoline (956907-14-5)

Guidance literature:

In N,N-dimethyl-formamide; at 70 ℃; for 3h; Inert atmosphere;

Reference yield:

quinolin-6-ylmethanamine (99071-54-2) → 6-((6-bromo-1H-[1,2,3]triazolo[4,5-b]pyrazine-1-yl)methyl)quinoline (956907-14-5)

Guidance literature:

Multi-step reaction with 2 steps

1: triethylamine / 5 h / 130 °C / Microwave irradiation

2: sodium nitrite; acetic acid / water / 3 h / 20 °C

With acetic acid; triethylamine; sodium nitrite; In water;

upstream raw materials:

6-bromo-N²-(quinolin-6-ylmethyl)pyrazine-2,3-diamine

quinolin-6-ylmethanamine

6-(hydroxymethyl)quinoline

6-(methoxycarbonyl)quinoline