99071-54-2 Usage
Description
6-Aminomethylquinoline, also known as 6-Quinolinemethanamine, is an organic compound with the chemical formula C10H9N. It is a derivative of quinoline, featuring an aminomethyl group attached to the 6th position of the quinoline ring. 6-Aminomethylquinoline is known for its potential applications in the pharmaceutical and chemical industries due to its unique chemical properties and reactivity.
Uses
Used in Pharmaceutical Industry:
6-Aminomethylquinoline is used as a reagent in the synthesis of novel 7-[(quinolin-6-yl)methyl] purines, which are potential c-Met inhibitors. These inhibitors are of interest in the development of targeted therapies for various cancers, as they can help regulate the activity of the c-Met receptor tyrosine kinase, a key player in tumor growth and progression.
In the synthesis process, 6-Aminomethylquinoline serves as a key intermediate, providing a platform for the attachment of various functional groups to create the desired purine-based c-Met inhibitors. The development of these inhibitors can contribute to the advancement of cancer treatment options, offering more targeted and effective therapies for patients.
Overall, 6-Aminomethylquinoline plays a significant role in the pharmaceutical industry, particularly in the development of novel compounds with potential therapeutic applications. Its unique structure and reactivity make it a valuable component in the synthesis of various bioactive molecules, paving the way for new discoveries and innovations in medicine.
Check Digit Verification of cas no
The CAS Registry Mumber 99071-54-2 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 9,9,0,7 and 1 respectively; the second part has 2 digits, 5 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 99071-54:
(7*9)+(6*9)+(5*0)+(4*7)+(3*1)+(2*5)+(1*4)=162
162 % 10 = 2
So 99071-54-2 is a valid CAS Registry Number.
InChI:InChI=1/C10H10N2/c11-7-8-3-4-10-9(6-8)2-1-5-12-10/h1-6H,7,11H2
99071-54-2Relevant articles and documents
Selective Hydrogenation of Nitriles to Primary Amines by using a Cobalt Phosphine Catalyst
Adam, Rosa,Bheeter, Charles Beromeo,Cabrero-Antonino, Jose R.,Junge, Kathrin,Jackstell, Ralf,Beller, Matthias
, p. 842 - 846 (2017/03/17)
A general procedure for the catalytic hydrogenation of nitriles to primary amines by using a non-noble metal-based system is presented. Co(acac)3 in combination with tris[2-(dicyclohexylphosphino)ethyl]phosphine efficiently catalyzes the selective hydrogenation of a wide range of (hetero)aromatic and aliphatic nitriles to give the corresponding amines.
Quinoline compounds and preparation method thereof, and intermediate, pharmaceutical composition and application of quinoline compounds
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, (2018/02/04)
The invention discloses quinoline compounds and a preparation method thereof, and an intermediate, a pharmaceutical composition and application of quinoline compounds. The invention provides quinoline compounds disclosed as Formula 1, and pharmaceutically acceptable salts, solvates, metabolites, metabolism precursors or pharmaceutical precursors thereof. The quinoline compounds have favorable inhibitory effects on tyrosine kinase C-Met, and can be used for preparing drugs for prevention, treatment or auxiliary treatment on multiple diseases related to C-Met expression or activity, and especially neoplastic diseases.
NOVEL 3,5-DISUBSTITUTED-3H-IMIDAZO[4,5-B]PYRIDINE AND 3,5- DISUBSTITUTED -3H-[1,2,3]TRIAZOLO[4,5-B] PYRIDINE COMPOUNDS AS MODULATORS OF C-MET PROTEIN, ETC
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, (2015/03/04)
The present invention provides compounds useful as c-Met protein kinase modulators, methods of preparing them, pharmaceutical compositions containing them and methods of treatment, prevention and/or amelioration of c-Met kinase mediated disease or disorders with them.