R-2-[bis[3,5-bis(trifluoroMethyl)phenyl] [(triethylsilyl)oxy]Methyl]-Pyrrolidine

Base Information

• Chemical Name: R-2-[bis[3,5-bis(trifluoroMethyl)phenyl] [(triethylsilyl)oxy]Methyl]-Pyrrolidine
• CAS No.: 1061307-56-9
• Molecular Formula: C27H29F12NOSi
• Molecular Weight: 639.6
• Mol file: 1061307-56-9.mol

Synonyms:Z-D-ALANINE-NH2;D-Z-Alanine amide;Cbz-D-Ala-NH2;CBZ-D-ALANINAMIDE;Z-D-ALANINE AMIDE;

Chemical Property of R-2-[bis[3,5-bis(trifluoroMethyl)phenyl] [(triethylsilyl)oxy]Methyl]-Pyrrolidine

Chemical Property:

• PSA: 21.26000
• LogP: 10.10800
• Storage Temp.: 2-8°C(protect from light)

Purity/Quality:

98%min ^*data from raw suppliers

Pyrrolidine,2-[bis[3,5-bis(trifluoromethyl)phenyl][(triethylsilyl)oxy]methyl]-,(2R)- 96% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of R-2-[bis[3,5-bis(trifluoroMethyl)phenyl] [(triethylsilyl)oxy]Methyl]-Pyrrolidine

There total 5 articles about R-2-[bis[3,5-bis(trifluoroMethyl)phenyl] [(triethylsilyl)oxy]Methyl]-Pyrrolidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

(R)-α,α-bis[3,5-bis(trifluoromethyl)phenyl]-2-pyrrolidinemethanol (948595-00-4) + triethylsilyl trifluoromethyl sulfonate (79271-56-0) → (2R)-2-(bis[3,5-bis(trifluoromethyl)phenyl][(triethylsilyl)oxy]methyl)pyrrolidine (1061307-56-9)

Guidance literature:

With 2,6-dimethylpyridine; In dichloromethane; at 20 ℃; for 21h; Inert atmosphere;

DOI:10.1021/ol900350k

Reference yield:

D-Prolin (344-25-2,25191-13-3,37159-97-0,4305-67-3,4607-28-7) → (2R)-2-(bis[3,5-bis(trifluoromethyl)phenyl][(triethylsilyl)oxy]methyl)pyrrolidine (1061307-56-9)

Guidance literature:

Multi-step reaction with 4 steps

1: potassium carbonate / Inert atmosphere

2: isopropylmagnesium chloride / tetrahydrofuran / Inert atmosphere

3: potassium hydroxide / methanol / Heating; Inert atmosphere

4: 2,6-dimethylpyridine / dichloromethane / Inert atmosphere

With 2,6-dimethylpyridine; isopropylmagnesium chloride; potassium carbonate; potassium hydroxide; In tetrahydrofuran; methanol; dichloromethane;

DOI:10.1021/jacs.1c08756

Reference yield:

(7aR)-1,1-bis(3,5-bis(trifluoromethyl)phenyl)tetrahydropyrrolo[1,2-c]oxazol-3(1H)-one (1146629-85-7) → (2R)-2-(bis[3,5-bis(trifluoromethyl)phenyl][(triethylsilyl)oxy]methyl)pyrrolidine (1061307-56-9)

Guidance literature:

Multi-step reaction with 2 steps

1: potassium hydroxide / methanol / Heating; Inert atmosphere

2: 2,6-dimethylpyridine / dichloromethane / Inert atmosphere

With 2,6-dimethylpyridine; potassium hydroxide; In methanol; dichloromethane;

DOI:10.1021/jacs.1c08756

upstream raw materials:

(R)-α,α-bis[3,5-bis(trifluoromethyl)phenyl]-2-pyrrolidinemethanol

triethylsilyl trifluoromethyl sulfonate

(7aR)-1,1-bis(3,5-bis(trifluoromethyl)phenyl)tetrahydropyrrolo[1,2-c]oxazol-3(1H)-one

1-ethyl methyl (2R)-pyrrolidine-1,2-dicarboxylate

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 1061307-56-9 R-2-[bis[3,5-bis(trifluoroMethyl)phenyl] [(triethylsilyl)oxy]Methyl]-Pyrrolidine

Send

Send

Metric Ton KG G Pound L ML

Send

Send