(7aR)-1,1-bis(3,5-bis(trifluoromethyl)phenyl)tetrahydropyrrolo[1,2-c]oxazol-3(1H)-one

Base Information

Chemical Name:(7aR)-1,1-bis(3,5-bis(trifluoromethyl)phenyl)tetrahydropyrrolo[1,2-c]oxazol-3(1H)-one
CAS No.:1146629-85-7
Molecular Formula:C₂₂H₁₃F₁₂NO₂
Molecular Weight:551.332
Hs Code.:

Synonyms:(7aR)-1,1-bis(3,5-bis(trifluoromethyl)phenyl)tetrahydropyrrolo[1,2-c]oxazol-3(1H)-one

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Chemical Property of (7aR)-1,1-bis(3,5-bis(trifluoromethyl)phenyl)tetrahydropyrrolo[1,2-c]oxazol-3(1H)-one

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Technology Process of (7aR)-1,1-bis(3,5-bis(trifluoromethyl)phenyl)tetrahydropyrrolo[1,2-c]oxazol-3(1H)-one

There total 2 articles about (7aR)-1,1-bis(3,5-bis(trifluoromethyl)phenyl)tetrahydropyrrolo[1,2-c]oxazol-3(1H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 328-70-1
3,6-bis(trifluoromethyl)bromobenzene

: 185246-66-6
1-ethyl methyl (2R)-pyrrolidine-1,2-dicarboxylate

: 1146629-85-7
(7aR)-1,1-bis(3,5-bis(trifluoromethyl)phenyl)tetrahydropyrrolo[1,2-c]oxazol-3(1H)-one

Guidance literature:: 3,6-bis(trifluoromethyl)bromobenzene; With isopropylmagnesium chloride; In tetrahydrofuran; at 0 ℃; for 1h; Inert atmosphere;

1-ethyl methyl (2R)-pyrrolidine-1,2-dicarboxylate; In tetrahydrofuran; at 0 - 65 ℃; Inert atmosphere;
DOI:10.1021/ol900350k

Reference yield:

: 344-25-2,25191-13-3,37159-97-0,4305-67-3,4607-28-7
D-Prolin

: 1146629-85-7
(7aR)-1,1-bis(3,5-bis(trifluoromethyl)phenyl)tetrahydropyrrolo[1,2-c]oxazol-3(1H)-one

Guidance literature:: Multi-step reaction with 2 steps

1: potassium carbonate / Inert atmosphere

2: isopropylmagnesium chloride / tetrahydrofuran / Inert atmosphere

With isopropylmagnesium chloride; potassium carbonate; In tetrahydrofuran;
DOI:10.1021/jacs.1c08756