6-Bromo-2-chloro-8-methoxyquinazoline

Base Information

• Chemical Name: 6-Bromo-2-chloro-8-methoxyquinazoline
• CAS No.: 953039-14-0
• Molecular Formula: C9H6BrClN2O
• Molecular Weight: 273.516
• Hs Code.: 2933990090
• Mol file: 953039-14-0.mol

Synonyms:6-BROMO-2-CHLORO-8-METHOXYQUINAZOLINE;6-bromo-4-chloro-7-methoxyquinazoline;6-Bromo-2-chloro-8-methox...;6-broMo-4-chloro-8-Methoxyquinazoline

Chemical Property of 6-Bromo-2-chloro-8-methoxyquinazoline

Chemical Property:

• Boiling Point: 342.1±35.0 °C at 760 mmHg
• Flash Point: 160.7±25.9 °C
• PSA: 35.01000
• Density: 1.7±0.1 g/cm³
• LogP: 3.05430
• Storage Temp.: 2-8°C

Purity/Quality:

99%, ^*data from raw suppliers

6-Bromo-2-chloro-8-methoxyquinazoline ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 6-Bromo-2-chloro-8-methoxyquinazoline

There total 6 articles about 6-Bromo-2-chloro-8-methoxyquinazoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 31.2%

6-bromo-8-methoxyquinazolin-2-ol (953039-13-9) → 6-bromo-2-chloro-8-methoxyquinazoline (953039-14-0)

Guidance literature:

With trichlorophosphate; at 20 - 110 ℃;

Reference yield:

6-bromo-8-methoxy-1H-quinazolin-2-one (953039-13-9) → 6-bromo-2-chloro-8-methoxyquinazoline (953039-14-0)

Guidance literature:

With trichlorophosphate; for 0.5h; Reflux;

Reference yield:

2-amino-5-bromo-3-methoxy benzoic acid (864293-44-7) → 6-bromo-2-chloro-8-methoxyquinazoline (953039-14-0)

Guidance literature:

Multi-step reaction with 4 steps

1: borane-THF / tetrahydrofuran / 0 °C

2: manganese(IV) oxide / dichloromethane / 20 °C

3: 2 h / 180 °C

4: trichlorophosphate / 20 - 110 °C

With manganese(IV) oxide; borane-THF; trichlorophosphate; In tetrahydrofuran; dichloromethane;

upstream raw materials:

6-bromo-8-methoxyquinazolin-2-ol

6-bromo-8-methoxy-1H-quinazolin-2-one

2-amino-3-methoxybenzoic acid

2-amino-5-bromo-3-methoxy benzoic acid

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