(2E,4E,6R,7R)-ethyl7-(4-(dimethylamino) phenyl)-7-hydroxy-4,6-dimethylhepta-2,4-dienoate

Base Information

• Chemical Name: (2E,4E,6R,7R)-ethyl7-(4-(dimethylamino) phenyl)-7-hydroxy-4,6-dimethylhepta-2,4-dienoate
• CAS No.: 934246-98-7
• Molecular Formula: C19H27NO3
• Molecular Weight: 317.428
• Mol file: 934246-98-7.mol

Synonyms:(2E,4E,6R,7R)-ethyl7-(4-(diMethylaMino) phenyl)-7-hydroxy-4,6-diMethylhepta-2,4-dienoate;Ethyl (2E,4E,6R,7R)-7-[4-(dimethylamino)phenyl]-7-hydroxy-4,6-dimethylhepta-2,4-dienoate

Chemical Property of (2E,4E,6R,7R)-ethyl7-(4-(dimethylamino) phenyl)-7-hydroxy-4,6-dimethylhepta-2,4-dienoate

Chemical Property:

Purity/Quality:

97% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of (2E,4E,6R,7R)-ethyl7-(4-(dimethylamino) phenyl)-7-hydroxy-4,6-dimethylhepta-2,4-dienoate

There total 1 articles about (2E,4E,6R,7R)-ethyl7-(4-(dimethylamino) phenyl)-7-hydroxy-4,6-dimethylhepta-2,4-dienoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

ethyl (2E,4E)-(6R,7R)-7-(4-aminophenyl)-7-hydroxy-4,6-dimethylhepta-2,4-dienoate (934246-97-6) + formaldehyd (50-00-0,30525-89-4,61233-19-0) → ethyl (2E,4E)-(6R,7R)-7-[4-(dimethylamino)phenyl]-7-hydroxy-4,6-dimethylhepta-2,4-dienoate (934246-98-7)

Guidance literature:

ethyl (2E,4E)-(6R,7R)-7-(4-aminophenyl)-7-hydroxy-4,6-dimethylhepta-2,4-dienoate; formaldehyd; In tetrahydrofuran; water; at 20 ℃; for 0.166667h;

With sodium tris(acetoxy)borohydride; In tetrahydrofuran; water; at 20 ℃; for 10h;

DOI:10.1002/adsc.200606106

Reference yield:

ethyl (2E,4E)-(6R,7R)-7-[4-(dimethylamino)phenyl]-7-hydroxy-4,6-dimethylhepta-2,4-dienoate (934246-98-7) → trichostatin A (58880-19-6,122292-85-7)

Guidance literature:

Multi-step reaction with 2 steps

1: NH₂OH / methanol / 2 h / 20 °C

2: 65 mg / DDQ / dioxane / 20 °C

With hydroxylamine; 2,3-dicyano-5,6-dichloro-p-benzoquinone; In 1,4-dioxane; methanol;

DOI:10.1002/adsc.200606106

Reference yield:

ethyl (2E,4E)-(6R,7R)-7-[4-(dimethylamino)phenyl]-7-hydroxy-4,6-dimethylhepta-2,4-dienoate (934246-98-7) → (2E,4E)-(6R,7R)-7-[4-(dimethylamino)phenyl]-N,7-dihydroxy-4,6-dimethylhepta-2,4-dienamide

Guidance literature:

With hydroxylamine; In methanol; at 20 ℃; for 2h;

DOI:10.1002/adsc.200606106

upstream raw materials:

ethyl (2E,4E)-(6R,7R)-7-(4-aminophenyl)-7-hydroxy-4,6-dimethylhepta-2,4-dienoate

formaldehyd

Downstream raw materials:

trichostatin A