2-(6-bromopyridin-2-yl)ethanol

Base Information

• Chemical Name: 2-(6-bromopyridin-2-yl)ethanol
• CAS No.: 955370-07-7
• Molecular Formula: C7H8BrNO
• Molecular Weight: 202.05
• Hs Code.: 2933399090
• Mol file: 955370-07-7.mol

Synonyms:2-(3-AMINO-PHENYL)-BENZOOXAZOL-5-YLAMINE;2-(6-BROMOPYRIDIN-2-YL)ETHAN-1-OL;

Chemical Property of 2-(6-bromopyridin-2-yl)ethanol

Chemical Property:

• Boiling Point: 292.0±25.0 °C(Predicted)
• PKA: 14.37±0.10(Predicted)
• PSA: 33.12000
• Density: 1.564±0.06 g/cm3(Predicted)
• LogP: 1.37890
• Storage Temp.: Inert atmosphere,Room Temperature

Purity/Quality:

97% ^*data from raw suppliers

2-(6-Bromopyridin-2-yl)ethanol ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 2-(6-bromopyridin-2-yl)ethanol is used in the preparation of 2,6-diaminopyridine compounds for treating diseases associated with amyloid or amyloid-like proteins, especially ocular diseases.

Technology Process of 2-(6-bromopyridin-2-yl)ethanol

There total 7 articles about 2-(6-bromopyridin-2-yl)ethanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

2-bromo-6-methylpyridine (5315-25-3) + N,N-dimethyl-formamide (68-12-2,33513-42-7) → 2-(6-bromopyridin-2-yl)ethan-1-ol (955370-07-7)

Guidance literature:

2-bromo-6-methylpyridine; With lithium diisopropyl amide; In tetrahydrofuran; at -78 ℃; for 0.833333h;

N,N-dimethyl-formamide; In tetrahydrofuran; at -78 ℃; for 0.5h;

With methanol; sodium tetrahydroborate; acetic acid; In tetrahydrofuran; at -78 ℃;

Reference yield: 82.0%

(6-bromo-pyridin-2-yl)-acetic acid ethyl ester (955369-63-8) → 2-(6-bromopyridin-2-yl)ethan-1-ol (955370-07-7)

Guidance literature:

With diisobutylaluminium hydride; In tetrahydrofuran; at 0 - 20 ℃; for 18h;

DOI:10.1002/anie.201907206

Reference yield: 76.5%

2-Bromo-4-picoline (4926-28-7) + N,N-dimethyl-formamide (68-12-2,33513-42-7) → 2-(6-bromopyridin-2-yl)ethan-1-ol (955370-07-7)

Guidance literature:

2-Bromo-4-picoline; With lithium diisopropyl amide; In tetrahydrofuran; at -70 ℃; for 0.5h; Inert atmosphere;

N,N-dimethyl-formamide; In tetrahydrofuran; at -70 ℃; for 0.25h; Further stages; Inert atmosphere;

upstream raw materials:

2-bromo-6-methylpyridine

N,N-dimethyl-formamide

2-Bromo-4-picoline

acetic acid

Downstream raw materials:

C₂₅H₃₆N₄O₅

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 955370-07-7 2-(6-bromopyridin-2-yl)ethanol

Send

Send

Metric Ton KG G Pound L ML

Send

Send