NO-LOSARTAN A

Base Information

• Chemical Name: NO-LOSARTAN A
• CAS No.: 791122-48-0
• Molecular Formula: C₃₀H₂₈ClN₇O₅
• Molecular Weight: 602.049
• Mol file: 791122-48-0.mol

Synonyms:;[2-BUTYL-4-CHLORO-1-[[2'-(1H-TETRAZOL-5-YL)[1,1'-BIPHENYL]-4-YL]METHYL]-1H-IMIDAZOL-5-YL] METHYL ESTER 3-[(NITROOXY)METHYL]-BENZOIC ACID;

Chemical Property of NO-LOSARTAN A

Chemical Property:

• PSA: 153.63000
• LogP: 6.36300

Purity/Quality:

≥97% ^*data from raw suppliers

NO-Losartan A ≥97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of NO-LOSARTAN A

There total 2 articles about NO-LOSARTAN A which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

lorsartan (114798-26-4) + 3‐[(nitrooxy)methyl]benzoic acid (646511-09-3) → 3-nitrooxymethyl-benzoic acid 2-butyl-5-chloro-3-[2'-(1H-tetrazol-5-yl)-biphenyl-4-ylmethyl]-3H-imidazol-4-ylmethyl ester (791122-48-0)

Guidance literature:

With dmap; dicyclohexyl-carbodiimide; In tetrahydrofuran; at 20 ℃; for 2h;

DOI:10.1021/jm049681p

Reference yield:

3-chloromethylbenzoic acid (31719-77-4) → 3-nitrooxymethyl-benzoic acid 2-butyl-5-chloro-3-[2'-(1H-tetrazol-5-yl)-biphenyl-4-ylmethyl]-3H-imidazol-4-ylmethyl ester (791122-48-0)

Guidance literature:

Multi-step reaction with 2 steps

1: 78 percent / AgNO₃ / acetonitrile / 2 h / 20 °C

2: 72 percent / DCC; DMAP / tetrahydrofuran / 2 h / 20 °C

With dmap; silver nitrate; dicyclohexyl-carbodiimide; In tetrahydrofuran; acetonitrile;

DOI:10.1021/jm049681p

upstream raw materials:

lorsartan

3‐[(nitrooxy)methyl]benzoic acid

3-chloromethylbenzoic acid