Ethyl-carbaMicacidpiperidin-4-ylester

Base Information

• Chemical Name: Ethyl-carbaMicacidpiperidin-4-ylester
• CAS No.: 70724-24-2
• Molecular Formula: C8H16N2O2
• Molecular Weight: 172.22
• Hs Code.: 2933399090
• Mol file: 70724-24-2.mol

Synonyms:4-piperidine ethyl carbamate;QC-8532;ethyl-carbamic acid piperidin-4-yl ester;Piperidin-4-yl ethylcarbamate;

Chemical Property of Ethyl-carbaMicacidpiperidin-4-ylester

Chemical Property:

• Boiling Point: 286.9±29.0 °C(Predicted)
• PKA: 12.72±0.46(Predicted)
• PSA: 53.85000
• Density: 1.06±0.1 g/cm3(Predicted)
• LogP: 1.01770
• Solubility.: CDCl3, Methanol

Purity/Quality:

≥99% ^*data from raw suppliers

Ethylcarbamic Acid 4-Piperidinyl Ester ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: Ethyl-carbaMicacidpiperidin-4-ylester is a useful reactant in the preparation Carbazeran (C175790), a phosphodiesterase inhibitor drug. A useful reactant in the preparation Carbazeran (C175790), a phosphodiesterase inhibitor drug.

Technology Process of Ethyl-carbaMicacidpiperidin-4-ylester

There total 2 articles about Ethyl-carbaMicacidpiperidin-4-ylester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

1-benzyl-4-hydroxypiperidine (4727-72-4) + 1,2-dichloro-ethane (107-06-2,52399-93-6) + ethyl isocyanate (109-90-0) → 4-(N-ethylcarbamoyloxy)piperidine (70724-24-2)

Guidance literature:

In palladium on charcoal catalyst; hexane; ethyl acetate;

Reference yield:

→ 4-(N-ethylcarbamoyloxy)piperidine (70724-24-2)

Guidance literature:

d. Bzl.-Verb., H2;

Reference yield:

4-(N-ethylcarbamoyloxy)piperidine (70724-24-2) + 1-chloro-6,7-dimethoxyphthalazine (70724-23-1) → Carbazeran (70724-25-3)

Guidance literature:

In methanol; i-Amyl alcohol; chloroform; water; ethyl acetate; acetonitrile;

upstream raw materials:

1-benzyl-4-hydroxypiperidine

1,2-dichloro-ethane

ethyl isocyanate

Downstream raw materials:

Carbazeran

Refernces

• 1、 -. "1-PIPERIDINOPHTHALAZINES AS CARDIAC STIMULANTS". . . Retrieved 2008/06/13.