5-BroMo-3-tert-butoxycarbonylaMino-thiophene-2-carboxylicacidMethylester

Base Information

Chemical Name:5-BroMo-3-tert-butoxycarbonylaMino-thiophene-2-carboxylicacidMethylester
CAS No.:946604-99-5
Molecular Formula:C₁₁H₁₄BrNO₄S
Molecular Weight:336.206
Hs Code.:2934999090
Mol file:946604-99-5.mol

Synonyms:Methyl 5-bromo-3-((tert-butoxycarbonyl)amino)thiophene-2-carboxylate;QC-8461;3-(tert-butoxycarbonyl)amino-5-bromo-thiophene-2-carboxylic acid methyl ester;5-Bromo-3-tert-butoxycarbonylamino-thiophene-2-carboxylic acid methyl ester;

Suppliers and Price of 5-BroMo-3-tert-butoxycarbonylaMino-thiophene-2-carboxylicacidMethylester

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Crysdot
Methyl5-bromo-3-((tert-butoxycarbonyl)amino)thiophene-2-carboxylate 95+%
1g
$ 455.00

Chemenu
methyl5-bromo-3-((tert-butoxycarbonyl)amino)thiophene-2-carboxylate 95%
1g
$ 430.00

Chemcia Scientific
5-Bromo-3-tert-butoxycarbonylamino-thiophene-2-carboxylicacidmethylester 97%
0.5 G
$ 265.00

Arctom
Methyl5-bromo-3-((tert-butoxycarbonyl)amino)thiophene-2-carboxylate ≥95%
1g
$ 186.00

Alichem
Methyl5-bromo-3-((tert-butoxycarbonyl)amino)thiophene-2-carboxylate
1g
$ 609.00

Alichem
Methyl5-bromo-3-((tert-butoxycarbonyl)amino)thiophene-2-carboxylate
250mg
$ 265.96

Total 10 raw suppliers

Chemical Property of 5-BroMo-3-tert-butoxycarbonylaMino-thiophene-2-carboxylicacidMethylester

Chemical Property:

PSA：96.36000
LogP:3.65780
Storage Temp.:2-8°C

Purity/Quality:

98%min ^*data from raw suppliers

Methyl5-bromo-3-((tert-butoxycarbonyl)amino)thiophene-2-carboxylate 95+% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 5-BroMo-3-tert-butoxycarbonylaMino-thiophene-2-carboxylicacidMethylester

There total 4 articles about 5-BroMo-3-tert-butoxycarbonylaMino-thiophene-2-carboxylicacidMethylester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

: 149587-72-4
3-(tert-butoxycarboxamido)thiophen-2-formic acid methyl ester

: 946604-99-5
methyl 5-bromo-3-((tert-butoxycarbonyl)amino)thiophene-2-carboxylate

Guidance literature:: 3-(tert-butoxycarboxamido)thiophen-2-formic acid methyl ester; With lithium diisopropyl amide; In tetrahydrofuran; at -78 ℃;

With 1,2-dibromo-1,1,2,2-tetrafluoroethane; In tetrahydrofuran;
DOI:10.1016/j.bmcl.2003.10.067

Reference yield: 77.0%

: 107818-55-3
3-amino-5-bromo-thiophene-2-carboxylic acid methyl ester

: 24424-99-5
di-tert-butyl dicarbonate

: 946604-99-5
methyl 5-bromo-3-((tert-butoxycarbonyl)amino)thiophene-2-carboxylate

Guidance literature:: With pyridine; dmap; at 0 - 20 ℃; for 15h; Inert atmosphere;

Reference yield:

: 22288-78-4
Methyl 3-aminothiophene-2-carboxylate

: 946604-99-5
methyl 5-bromo-3-((tert-butoxycarbonyl)amino)thiophene-2-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: dmap; triethylamine / dichloromethane / 3 h / 25 °C

2: lithium diisopropyl amide; 1,2-dibromo-1,1,2,2-tetrafluoroethane / tetrahydrofuran / 1 h / -78 °C

With dmap; 1,2-dibromo-1,1,2,2-tetrafluoroethane; triethylamine; lithium diisopropyl amide; In tetrahydrofuran; dichloromethane;