ZALEPLON-D5

Base Information

• Chemical Name: ZALEPLON-D5
• CAS No.: 1001083-56-2
• Molecular Formula: C₁₇H₁₅N₅O
• Molecular Weight: 310.299

Synonyms:ZALEPLON-D5;CL-284846-d5;N-[3-(3-Cyanopyrazolo[1,5-a]pyrimidin-7-yl)phenyl]-N-ethyl-d5-acetamide;Sonata-d5

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Chemical Property of ZALEPLON-D5

Chemical Property:

• Melting Point: 181-1840C
• PSA: 74.29000
• LogP: 2.64078
• Storage Temp.: Controlled Substance, -20°C Freezer
• Solubility.: Chloroform (Slightly), Methanol (Slightly)

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: Selective non-benzodiazepine GABAA receptor agonist.

Technology Process of ZALEPLON-D5

There total 2 articles about ZALEPLON-D5 which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

N-[3-(3-dimethylamino-acryloyl)phenyl]-N-[d5]-ethyl-acetamide (1104483-92-2) + 7-(3-nitrophenyl)-pyrazolo[1,5-a]pyrimidine-3-carbonitrile (115930-99-9) → N-[3-(3-cyano-pyrazolo[1,5-a]pyrimidin-7-yl)phenyl]-N-[2H5]-ethyl-acetamide (1001083-56-2)

Guidance literature:

With acetic acid; at 50 ℃; for 2h;

DOI:10.1002/jlcr.1484

Reference yield: 20.0%

iodoethane-d5 (6485-58-1) + N-[3-(3-cyano-pyrazolo[1,5-a]pyrimidin-7-yl)phenyl]acetamide (115931-01-6) → N-[3-(3-cyano-pyrazolo[1,5-a]pyrimidin-7-yl)phenyl]-N-[2H5]-ethyl-acetamide (1001083-56-2)

Guidance literature:

With sodium hydride; In tetrahydrofuran; at 50 ℃; for 60h;

DOI:10.1002/jlcr.1484

upstream raw materials:

N-[3-(3-dimethylamino-acryloyl)phenyl]-N-[d5]-ethyl-acetamide

7-(3-nitrophenyl)-pyrazolo[1,5-a]pyrimidine-3-carbonitrile

iodoethane-d5

N-[3-(3-cyano-pyrazolo[1,5-a]pyrimidin-7-yl)phenyl]acetamide